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耐力运动对大鼠心脏、骨骼肌和肝脏线粒体中肉碱棕榈酰转移酶I的影响。

Effects of endurance exercise on carnitine palmitoyltransferase I from rat heart, skeletal muscle and liver mitochondria.

作者信息

Guzmán M, Castro J

机构信息

Department of Biochemistry, Faculty of Chemistry, Universidad Complutense, Madrid, Spain.

出版信息

Biochim Biophys Acta. 1988 Dec 16;963(3):562-5. doi: 10.1016/0005-2760(88)90327-x.

DOI:10.1016/0005-2760(88)90327-x
PMID:3196751
Abstract

Prolonged physical exercise increased the activity of carnitine palmitoyltransferase I in rat heart and skeletal muscle mitochondria, whereas enzyme sensitivity to inhibition by malonyl-CoA remained unchanged. Nevertheless, inhibition of carnitine palmitoyltransferase I activity by small decreases in pH was attenuated in heart and skeletal muscle mitochondria from exercised animals. Liver enzyme did not suffer any alteration by endurance exercise.

摘要

长时间体育锻炼增加了大鼠心脏和骨骼肌线粒体中肉碱棕榈酰转移酶I的活性，而该酶对丙二酰辅酶A抑制的敏感性保持不变。然而，在运动动物的心脏和骨骼肌线粒体中，pH值小幅下降对肉碱棕榈酰转移酶I活性的抑制作用减弱。耐力运动并未使肝脏中的该酶发生任何改变。

相似文献

1
Effects of endurance exercise on carnitine palmitoyltransferase I from rat heart, skeletal muscle and liver mitochondria.耐力运动对大鼠心脏、骨骼肌和肝脏线粒体中肉碱棕榈酰转移酶I的影响。
Biochim Biophys Acta. 1988 Dec 16;963(3):562-5. doi: 10.1016/0005-2760(88)90327-x.
2
Carnitine acyltransferase activities in rat liver and heart measured with palmitoyl-CoA and octanoyl-CoA. Latency, effects of K+, bivalent metal ions and malonyl-CoA.用棕榈酰辅酶A和辛酰辅酶A测定大鼠肝脏和心脏中的肉碱酰基转移酶活性。潜伏性、钾离子、二价金属离子和丙二酰辅酶A的影响。
Biochem J. 1982 Feb 15;202(2):397-405. doi: 10.1042/bj2020397.
3
Effects of pH on the interaction of substrates and malonyl-CoA with mitochondrial carnitine palmitoyltransferase I.pH对底物和丙二酰辅酶A与线粒体肉碱棕榈酰转移酶I相互作用的影响
Biochem J. 1984 Apr 15;219(2):601-8. doi: 10.1042/bj2190601.
4
Interaction of malonyl-CoA and related compounds with mitochondria from different rat tissues. Relationship between ligand binding and inhibition of carnitine palmitoyltransferase I.丙二酰辅酶A及相关化合物与不同大鼠组织线粒体的相互作用。配体结合与肉碱棕榈酰转移酶I抑制之间的关系。
Biochem J. 1983 Jul 15;214(1):83-91. doi: 10.1042/bj2140083.
5
Are there two forms of carnitine palmitoyltransferase in muscle?肌肉中是否存在两种形式的肉碱棕榈酰转移酶？
Neurology. 1987 Nov;37(11):1785-90. doi: 10.1212/wnl.37.11.1785.
6
Interacting effects of L-carnitine and malonyl-CoA on rat liver carnitine palmitoyltransferase.左旋肉碱与丙二酰辅酶A对大鼠肝脏肉碱棕榈酰转移酶的相互作用
Biochem J. 1985 Aug 15;230(1):161-7. doi: 10.1042/bj2300161.
7
The effect of malonyl-CoA on overt and latent carnitine acyltransferase activities in rat liver and adipocyte mitochondria.丙二酰辅酶A对大鼠肝脏和脂肪细胞线粒体中显性和潜在肉碱酰基转移酶活性的影响。
Biochem J. 1983 Feb 15;210(2):591-7. doi: 10.1042/bj2100591.
8
The effect of fasting on the activity of liver carnitine palmitoyltransferase and its inhibition by malonyl-CoA.禁食对肝脏肉碱棕榈酰转移酶活性的影响及其被丙二酰辅酶A的抑制作用。
Biochim Biophys Acta. 1981 Sep 24;665(3):628-31. doi: 10.1016/0005-2760(81)90282-4.
9
Hysteretic behaviour of carnitine palmitoyltransferase. The effect of preincubation with malonyl-CoA.肉碱棕榈酰转移酶的滞后行为。丙二酰辅酶A预温育的影响。
Biochem J. 1986 Jun 15;236(3):917-9. doi: 10.1042/bj2360917.
10
Effect of malonyl-CoA on the kinetics and substrate cooperativity of membrane-bound carnitine palmitoyltransferase of rat heart mitochondria.丙二酰辅酶A对大鼠心脏线粒体膜结合肉碱棕榈酰转移酶动力学及底物协同性的影响。
Biochim Biophys Acta. 1987 Dec 18;916(3):482-92. doi: 10.1016/0167-4838(87)90195-6.

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Lipid-induced insulin resistance in the liver: role of exercise.肝脏中脂质诱导的胰岛素抵抗：运动的作用。
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Effect of different types of high carbohydrate diets on glycogen metabolism in liver and skeletal muscle of endurance-trained rats.
不同类型的高碳水化合物饮食对耐力训练大鼠肝脏和骨骼肌糖原代谢的影响。
Eur J Appl Physiol Occup Physiol. 1996;74(1-2):91-9. doi: 10.1007/BF00376500.
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Modulation of fatty-acid-binding protein content of rat heart and skeletal muscle by endurance training and testosterone treatment.耐力训练和睾酮治疗对大鼠心脏和骨骼肌脂肪酸结合蛋白含量的调节作用。
Pflugers Arch. 1992 Jun;421(2-3):274-9. doi: 10.1007/BF00374838.