Ingwersen W, Allen D G, Dyson D H, Black W D, Goldberg M T, Valliant A E
Department of Clinical Studies, Ontario Veterinary College, University of Guelph.
Can J Vet Res. 1988 Oct;52(4):423-7.
The cardiopulmonary effects of a ketamine/ acepromazine combination was studied in ten cats subjected to a 25% whole blood volume loss. Test parameters included cardiac output, measured via thermodilution, heart rate, respiratory rate, arterial blood pressure (systolic, diastolic and mean) and blood gas analysis. Values for cardiac index, stroke volume and systemic vascular resistance were calculated from these data. Posthemorrhage, cardiac output, cardiac index, stroke volume, heart rate and measurements of arterial blood pressure were significantly decreased (p less than 0.05). Following the induction of ketamine/ acepromazine anesthesia, cardiac output, cardiac index, stroke volume and heart rate showed mild but statistically insignificant declines and were above their respective posthemorrhage values 120 min into ketamine/ acepromazine anesthesia. Measurements of arterial blood pressure showed further declines from their respective posthemorrhage values that were statistically significant (p less than 0.05). Following hemorrhage, respiratory rate increased significantly (p less than 0.05), associated with a fall in arterial CO2 tension. During ketamine/ acepromazine anesthesia, respiratory rate showed a dramatic and significant decline (p less than 0.05) with arterial CO2 tension rising to prehemorrhage values. Systemic vascular resistance, arterial O2 tension and pH remained essentially unchanged throughout the experimental period.
研究了氯胺酮/乙酰丙嗪组合对10只经历25%全血容量丢失的猫的心肺效应。测试参数包括通过热稀释法测量的心输出量、心率、呼吸频率、动脉血压（收缩压、舒张压和平均压）以及血气分析。根据这些数据计算心脏指数、每搏输出量和全身血管阻力的值。出血后，心输出量、心脏指数、每搏输出量、心率和动脉血压测量值显著降低（p<0.05）。在诱导氯胺酮/乙酰丙嗪麻醉后，心输出量、心脏指数、每搏输出量和心率显示出轻微但无统计学意义的下降，并且在氯胺酮/乙酰丙嗪麻醉120分钟时高于各自的出血后值。动脉血压测量值从各自的出血后值进一步下降，具有统计学意义（p<0.05）。出血后，呼吸频率显著增加（p<0.05），与动脉血二氧化碳张力下降有关。在氯胺酮/乙酰丙嗪麻醉期间，呼吸频率显著急剧下降（p<0.05），动脉血二氧化碳张力升至出血前值。在整个实验期间，全身血管阻力、动脉血氧张力和pH基本保持不变。
