Faculty of Dentistry, Oral Medicine, Periodontology, Diagnosis and Radiology Department, Alexandria University, Alexandria, Egypt.
Faculty of Science, Biochemistry Department, Alexandria University, Alexandria, Egypt.
Oral Dis. 2020 May;26(4):789-804. doi: 10.1111/odi.13285. Epub 2020 Feb 10.
Oral lichen planus (OLP) is a chronic disease with immune-mediated pathogenesis. Selenium (Se), an antioxidant, plays a role in modulating immunity. The aim of this clinical trial was to evaluate two Se forms (novel topical hydrogel and oral capsules), solely, in treating erosive OLP based on clinical evaluation and salivary oxidative stress markers. Patients were allocated into one of three groups: group I, topical corticosteroids; group II, topical Se; and group III, systemic Se. Treatment lasted for 6 weeks; patients were clinically evaluated at baseline, 6, and 12 weeks. Biochemical analysis for salivary malondialdehyde (MDA) and total antioxidant capacity (TAC) levels at baseline and 6 weeks was performed. There was a significant reduction in signs and symptoms in response to all treatment modalities. However, there was no significant difference among the three groups at 6 weeks. At 12 weeks, group II had significantly lower pain scores compared with group I. Salivary MDA levels showed a significant decrease in patients of group I and group III. TAC levels showed no significant difference in response to treatment. Selenium can be proposed as a treatment for OLP. Salivary MDA levels can be a biomarker for OLP disease severity.
口腔扁平苔藓（OLP）是一种具有免疫介导发病机制的慢性疾病。硒（Se）作为一种抗氧化剂，在调节免疫方面发挥作用。本临床试验旨在根据临床评估和唾液氧化应激标志物，单独评估两种硒形式（新型局部水凝胶和口服胶囊）在治疗糜烂性 OLP 中的作用。患者被分配到以下三组之一：I 组，局部皮质类固醇；II 组，局部硒；III 组，全身硒。治疗持续 6 周；患者在基线、6 周和 12 周时进行临床评估。在基线和 6 周时进行唾液丙二醛（MDA）和总抗氧化能力（TAC）水平的生化分析。所有治疗方法均显著减轻了症状和体征。然而，6 周时三组之间没有显著差异。12 周时，II 组的疼痛评分明显低于 I 组。I 组和 III 组患者的唾液 MDA 水平显著降低。TAC 水平对治疗无明显差异。硒可以被提议作为 OLP 的治疗方法。唾液 MDA 水平可以作为 OLP 疾病严重程度的生物标志物。
