从内生真菌中分离得到的一种植物中，得到了两种新的倍半萜。
Two new nor-sesquiterpenoids from , an endophytic fungus isolated from .
机构信息
The Ministry of Education Key Laboratory of Standardization of Chinese Herbal Medicine, State Key Laboratory, Breeding Base of Systematic Research Development and Utilization of Chinese Medicine Resources, School of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
Institute of Innovative Medicine Ingredients of Southwest Specialty Medicinal Materials, Chengdu University of Traditional Chinese Medicine, Chengdu, P. R. China.
出版信息
Nat Prod Res. 2021 Nov;35(21):3535-3539. doi: 10.1080/14786419.2020.1712385. Epub 2020 Jan 24.
As part of our search for compounds with cytotoxicity from endophytes of traditional Chinese medicines, two novel nor-sesquiterpenoids (-) with a new skeleton containing a tetrahydrofuran moiety were isolated form a rice medium of , an endophytic fungus isolated from the root of . The structures of these two previously undescribed compounds were elucidated by interpretation of the spectroscopic evidences including NMR correlations as well as MS data. The absolute configurations of these two compounds were confirmed by TD-DFT-ECD calculations. An MTT assay indicated that compound exhibited moderate cytotoxic activity against MV4-11 with an IC value of 22.29 μM.
作为从中药内生真菌中寻找具有细胞毒性的化合物的研究工作的一部分，我们从一株内生真菌（ ）的大米培养基中分离得到了两个新型的倍半萜类化合物（-），它们具有一个包含四氢呋喃部分的全新骨架。通过解析包括 NMR 相关谱以及 MS 数据在内的光谱证据，阐明了这两个以前未被描述的化合物的结构。通过 TD-DFT-ECD 计算确定了这两个化合物的绝对构型。MTT 测定表明，化合物 对 MV4-11 具有中等的细胞毒性，IC 值为 22.29 μM。
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