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内生菌菌株：天然产物的宝库。

The endophytic strains: a treasure trove of natural products.

作者信息

Ahmed Arwa Mortada, Mahmoud Basma Khalaf, Millán-Aguiñaga Natalie, Abdelmohsen Usama Ramadan, Fouad Mostafa Ahmed

机构信息

Department of Pharmacognosy, Faculty of Pharmacy, Deraya University 61111 New Minia City Egypt.

Department of Pharmacognosy, Faculty of Pharmacy, Minia University 61519 Minia Egypt

出版信息

RSC Adv. 2023 Jan 9;13(2):1339-1369. doi: 10.1039/d2ra04126j. eCollection 2023 Jan 3.

DOI:10.1039/d2ra04126j
PMID:36686899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9827111/
Abstract

The complexity and structural diversity of the secondary metabolites produced by endophytes make them an attractive source of natural products with novel structures that can help in treating life-changing diseases. The genus is one of the most abundant endophytic fungal genera, comprising about 70 species characterized by extraordinary discrepancy in terms of genetics and ability to grow on a wide range of substrates, affecting not only their biology and interaction with their surrounding organisms, but also their secondary metabolism. Members of the genus are a source of secondary metabolites with structural and chemical diversity and reported to exhibit diverse pharmacological activities. This comprehensive review focuses on the secondary metabolites isolated from different endophytic species along with their various biological activities, reported in the period from April 1999 to April 2022.

摘要

内生菌产生的次生代谢产物具有复杂性和结构多样性，这使其成为具有新颖结构的天然产物的诱人来源，有助于治疗改变生活的疾病。该属是最丰富的内生真菌属之一，包含约70个物种，其特点是在遗传学和在多种底物上生长的能力方面存在显著差异，这不仅影响它们的生物学特性以及与周围生物的相互作用，还影响它们的次生代谢。该属成员是具有结构和化学多样性的次生代谢产物的来源，并据报道具有多种药理活性。这篇综述聚焦于1999年4月至2022年4月期间报道的从不同内生该属物种中分离出的次生代谢产物及其各种生物活性。

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