来源于内生真菌拟茎点霉的倍半萜。
Sesquiterpenoids from the Endophytic Fungus Rhinocladiella similis.
机构信息
Institute of Pharmaceutical Biology and Biotechnology , Heinrich-Heine-Universität Düsseldorf , 40225 Düsseldorf , Germany.
Faculty of Life Science and Food Engineering , Huaiyin Institute of Technology , Huaian 223003 , People's Republic of China.
出版信息
J Nat Prod. 2019 May 24;82(5):1055-1062. doi: 10.1021/acs.jnatprod.8b00938. Epub 2019 May 2.
Ten new sesquiterpenoid derivatives, rhinomilisins A-J (1-10), along with six known analogues (11-16), were isolated from the mangrove-derived endophytic fungus Rhinocladiella similis. The structures of the new compounds were elucidated by their NMR and MS data, while the absolute configuration of 3 and 6 was determined by X-ray crystallographic analysis and Mosher's method, respectively. All isolated compounds (1-16) were evaluated for their cytotoxicity against the mouse lymphoma cell line L5178Y, and compounds 1, 7, and 15 showed moderate activity with IC values of 5.0, 8.7, and 24.4 μM, respectively.
从红树林内生真菌 Rhinocladiella similis 中分离得到了 10 个新的倍半萜类衍生物 rhinomilisins A-J（1-10），以及 6 个已知类似物（11-16）。通过 NMR 和 MS 数据阐明了新化合物的结构，而 3 和 6 的绝对构型则分别通过 X 射线晶体学分析和 Mosher 法确定。对所有分离得到的化合物（1-16）进行了对小鼠淋巴瘤细胞系 L5178Y 的细胞毒性评价，化合物 1、7 和 15 表现出中等活性，IC 值分别为 5.0、8.7 和 24.4 μM。
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