Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran.
Department of Diagnostic Genetics, LabPLUS, Auckland City Hospital, Auckland District Health Board (ADHB), Auckland, New Zealand.
Pathog Dis. 2019 Dec 1;77(9). doi: 10.1093/femspd/ftaa004.
Helicobacter pylori infection performs a key role in gastric tumorigenesis. Long non-coding RNAs (lncRNAs) have demonstrated a great potential to be regarded as effective malignancy biomarkers for various gastrointestinal diseases including gastric cancer (GC). The present review highlights the relationship between lncRNAs and H. pylori in GC. Several studies have examined not only the involvement of lncRNAs in H. pylori-associated GC progression but also their molecular mechanisms of action. Among the pertinent studies, some have addressed the effects of H. pylori infection on modulatory networks of lncRNAs, while others have evaluated the effects of changes in the expression level of lncRNAs in H. pylori-associated gastric diseases, especially GC. The relationship between lncRNAs and H. pylori was found to be modulated by various molecular pathways.
幽门螺杆菌感染在胃肿瘤发生中起关键作用。长链非编码 RNA（lncRNA）已被证明具有作为各种胃肠道疾病（包括胃癌（GC））的有效恶性肿瘤标志物的巨大潜力。本综述重点介绍了 lncRNA 与 GC 中幽门螺杆菌之间的关系。一些研究不仅研究了 lncRNA 参与幽门螺杆菌相关 GC 进展的情况，还研究了其作用的分子机制。在相关研究中，一些研究了幽门螺杆菌感染对 lncRNA 调节网络的影响，而另一些研究则评估了 lncRNA 表达水平变化在幽门螺杆菌相关胃疾病，尤其是 GC 中的作用。发现 lncRNA 与幽门螺杆菌之间的关系受多种分子途径的调节。
