Student Research Committee, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmaceutical Nanotechnology Research Center, Faculty of Medicine, Tabriz University of Medical Sciences, Tabriz, Iran.
Biomed Res Int. 2021 Jul 9;2021:6911734. doi: 10.1155/2021/6911734. eCollection 2021.
() infection is the most common cause of gastric cancer (GC). This microorganism is genetically diverse; GC is caused by several genetic deregulations in addition to environmental factors and bacterial virulence factors. lncRNAs (long noncoding RNAs) are significant biological macromolecules in GC, have specific functions in diseases, and could be therapeutic targets. Altered lncRNAs can lead to the abnormal expression of adjacent protein-coding genes, which may be important in cancer development. Their mechanisms have not been well understood, so we are going to investigate the risk of GC in a population with both high lncRNA and infection.
幽门螺杆菌感染是胃癌（GC）最常见的原因。这种微生物具有遗传多样性；除了环境因素和细菌毒力因素外，GC 还由几种基因失调引起。lncRNAs（长非编码 RNA）是 GC 中的重要生物大分子，在疾病中有特定的功能，并且可能是治疗靶点。改变的 lncRNAs 可能导致邻近的蛋白质编码基因的异常表达，这在癌症发展中可能很重要。它们的机制尚未得到很好的理解，因此我们将研究在 lncRNA 和 感染均高的人群中 GC 的风险。
