Research Institute of General Surgery, Jinling Hospital, School of Medicine, Southeast University, Nanjing 210009, China.
Chicago Medical School, Rosalind Franklin University of Medicine and Science, North Chicago 60064, USA.
Int J Biol Macromol. 2020 Apr 15;149:148-157. doi: 10.1016/j.ijbiomac.2020.01.221. Epub 2020 Jan 23.
Konjac glucomannan is a biocompatible polysaccharide with high medicinal potential. In this study, we prepared a hydrogel using an optimized crosslinking konjac glucomannan and chitosan. Silver nanoparticles (AgNPs) were incorporated into the hydrogel to enhance its antimicrobial property. This nanocomposite hydrogel could absorb wound exudates due to its swelling ability, and showed self-healing property that enabled structure stability. Moreover, as a carrier, the hydrogel could modulate the release of silver ions burst, thereby reducing AgNPs cytotoxicity. Rats models with infected skin defects were used to assess wound healing. The results indicated that AgNPs hydrogels dressing could promote wound healing and reduce inflammatory response, exhibiting great clinical application potentials.
魔芋葡甘聚糖是一种具有高药用潜力的生物相容性多糖。在这项研究中，我们使用优化的交联魔芋葡甘聚糖和壳聚糖制备了一种水凝胶。将银纳米粒子（AgNPs）掺入水凝胶中以增强其抗菌性能。由于其高吸水性，这种纳米复合水凝胶可以吸收伤口渗出物，并具有自修复性能，可保持结构稳定性。此外，作为载体，水凝胶可以调节银离子的释放，从而降低 AgNPs 的细胞毒性。使用感染皮肤缺陷的大鼠模型评估伤口愈合情况。结果表明，AgNPs 水凝胶敷料可以促进伤口愈合，减轻炎症反应，具有巨大的临床应用潜力。
