Kulka-Kamińska Karolina, Kurzawa Marzanna, Sionkowska Alina
Department of Biomaterials and Cosmetic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland.
Department of Analytical Chemistry and Applied Spectroscopy, Faculty of Chemistry, Nicolaus Copernicus University in Torun, 7 Gagarin Street, 87-100 Torun, Poland.
Materials (Basel). 2025 Jan 20;18(2):457. doi: 10.3390/ma18020457.
Biopolymers represent a significant class of materials with potential applications in skin care due to their beneficial properties. Resveratrol is a natural substance that exhibits a range of biological activities, including the scavenging of free radicals and anti-inflammatory and anti-aging effects. In this study, chitosan/konjac glucomannan resveratrol-enriched thin films were prepared. The enrichment of biomaterials with active ingredients is a common practice, as it allows the desired properties to be obtained in the final product. To characterize the films, several analyses were performed, including infrared spectroscopy, imaging of the samples by SEM and AFM techniques, swelling analysis in pH 5.5 and 7.4, mechanical and antioxidant assays, contact angle measurements, and determination of the resveratrol release profile under the skin mimicking conditions. Resveratrol incorporation into the matrices resulted in modifications to the chemical structure and film morphology. The mechanical characteristics of films with additives were found to undergo deterioration. The sample containing 10% of resveratrol exhibited a higher swelling degree than other films. The resveratrol-modified films demonstrated a notable antioxidant capacity, a reduced contact angle, and enhanced wettability. The resveratrol release occurred rapidly initially, with a maximum of 84% and 56% of the substance released depending on the sample type. Thus, the proposed formulations have promising properties, in particular good swelling capacity, high antioxidant potential, and improved wettability, and may serve as skin dressings after further investigation.
生物聚合物是一类重要的材料，因其有益特性而在皮肤护理方面具有潜在应用。白藜芦醇是一种天然物质，具有一系列生物活性，包括清除自由基以及抗炎和抗衰老作用。在本研究中，制备了富含白藜芦醇的壳聚糖/魔芋葡甘露聚糖薄膜。用活性成分富集生物材料是一种常见做法，因为这样可以在最终产品中获得所需特性。为了表征这些薄膜，进行了多项分析，包括红外光谱分析、通过扫描电子显微镜（SEM）和原子力显微镜（AFM）技术对样品成像、在pH 5.5和7.4条件下的溶胀分析、机械性能和抗氧化性能测定、接触角测量以及在模拟皮肤条件下测定白藜芦醇的释放曲线。将白藜芦醇掺入基质导致化学结构和薄膜形态发生改变。发现添加添加剂的薄膜的机械性能有所下降。含有10%白藜芦醇的样品比其他薄膜表现出更高的溶胀度。白藜芦醇改性薄膜表现出显著的抗氧化能力、减小的接触角和增强的润湿性。白藜芦醇的释放最初迅速发生，根据样品类型，该物质的最大释放量分别为84%和56%。因此，所提出的配方具有良好的性能，特别是良好的溶胀能力、高抗氧化潜力和改善的润湿性，经过进一步研究后可作为皮肤敷料。
