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Mesenchymal Stromal Cell-Derived Exosomes Contribute to Epithelial Regeneration in Experimental Inflammatory Bowel Disease.

作者信息

Barnhoorn M C, Plug L, Jonge E S M Muller-de, Molenkamp D, Bos E, Schoonderwoerd M J A, Corver W E, van der Meulen-de Jong A E, Verspaget H W, Hawinkels L J A C

机构信息

Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, The Netherlands.

Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands.

出版信息

Cell Mol Gastroenterol Hepatol. 2020;9(4):715-717.e8. doi: 10.1016/j.jcmgh.2020.01.007. Epub 2020 Jan 23.

DOI:10.1016/j.jcmgh.2020.01.007
PMID:31982571
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7212470/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/03f9f3ace146/fx4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/c5b2125a5c84/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/32daa241c569/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/c9ac47785eee/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/7e8be9e000c2/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/ec55d8164892/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/03f9f3ace146/fx4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/c5b2125a5c84/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/32daa241c569/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/c9ac47785eee/fx1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/7e8be9e000c2/fx2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/ec55d8164892/fx3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a1dc/7212470/03f9f3ace146/fx4.jpg

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本文引用的文献

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Endoscopic Administration of Mesenchymal Stromal Cells Reduces Inflammation in Experimental Colitis.内镜下给予间充质基质细胞可减轻实验性结肠炎的炎症。
Inflamm Bowel Dis. 2018 Jul 12;24(8):1755-1767. doi: 10.1093/ibd/izy130.
2
The microRNA regulatory landscape of MSC-derived exosomes: a systems view.MSC 来源的外泌体中的 microRNA 调控图谱：系统视角。
Sci Rep. 2018 Jan 23;8(1):1419. doi: 10.1038/s41598-018-19581-x.
3
Inflammation-Stimulated Mesenchymal Stromal Cell-Derived Extracellular Vesicles Attenuate Inflammation.炎症刺激的间充质基质细胞衍生的细胞外囊泡可减轻炎症。
在胎儿间充质基质细胞衍生的外泌体中鉴定出的MFGE-8可改善急性肝衰竭病理。
iScience. 2023 Sep 30;26(11):108100. doi: 10.1016/j.isci.2023.108100. eCollection 2023 Nov 17.
4
Research Models to Mimic Necrotizing Enterocolitis and Inflammatory Bowel Diseases: Focus on Extracellular Vesicles Action.模拟坏死性小肠结肠炎和炎症性肠病的研究模型：重点关注细胞外囊泡的作用。
Stem Cells. 2023 Dec 14;41(12):1091-1100. doi: 10.1093/stmcls/sxad068.
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Secretome-based acellular therapy of bone marrow-derived mesenchymal stem cells in degenerative and immunological disorders: A narrative review.基于分泌组的骨髓间充质干细胞在退行性和免疫性疾病中的无细胞治疗：一项叙述性综述。
Heliyon. 2023 Jul 8;9(7):e18120. doi: 10.1016/j.heliyon.2023.e18120. eCollection 2023 Jul.
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HucMSC-Exo Promote Mucosal Healing in Experimental Colitis by Accelerating Intestinal Stem Cells and Epithelium Regeneration via Wnt Signaling Pathway.外泌体促进实验性结肠炎黏膜愈合的作用机制：通过 Wnt 信号通路加速肠干细胞和上皮细胞再生。
Int J Nanomedicine. 2023 May 25;18:2799-2818. doi: 10.2147/IJN.S402179. eCollection 2023.
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Local administration of mesenchymal stromal cells is safe and modulates the immune compartment in ulcerative proctitis.局部给予间充质基质细胞是安全的，并调节溃疡性直肠炎的免疫区室。
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Stem Cell Res Ther. 2021 May 29;12(1):315. doi: 10.1186/s13287-021-02404-8.
Stem Cells. 2018 Jan;36(1):79-90. doi: 10.1002/stem.2730. Epub 2017 Nov 16.
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Allogeneic Bone Marrow-Derived Mesenchymal Stromal Cells Promote Healing of Refractory Perianal Fistulas in Patients With Crohn's Disease.同种异体骨髓源间充质基质细胞促进克罗恩病患者难治性肛周瘘的愈合。
Gastroenterology. 2015 Oct;149(4):918-27.e6. doi: 10.1053/j.gastro.2015.06.014. Epub 2015 Jun 25.
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Synergistic effects of the sesquiterpene lactone, EPD, with cisplatin and paclitaxel in ovarian cancer cells.倍半萜内酯EPD与顺铂和紫杉醇在卵巢癌细胞中的协同作用。
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Interaction with colon cancer cells hyperactivates TGF-β signaling in cancer-associated fibroblasts.与结肠癌细胞的相互作用会使肿瘤相关成纤维细胞中的 TGF-β信号通路过度激活。
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