Li Guanghu, Zhang Kewei, Gong Fangchao, Jin Haiguo
Department of Thoracic Surgery, Jilin University First Hospital, Changchun, China.
J BUON. 2019 Nov-Dec;24(6):2322-2326.
To investigate the changes in blood glucose, blood lipid and inflammation in patients with ovarian cancer and their clinical significance.
67 patients diagnosed with ovarian cancer and treated in our hospital from January 2018 to December 2018 constituted the observation group. Fifty healthy women in the corresponding time period were enrolled as the control group. The levels of blood glucose, blood lipid and inflammation were compared between the two groups, and then the changes in those levels in ovarian cancer patients in different clinical stages were analyzed.
The levels of fasting blood glucose and 2-h postprandial blood glucose of the observation group were significantly higher than those of the control group, and they were also significantly higher in patients in stage III-IV than those in stage I-II (p<0.05). In the observation group, the levels of total cholesterol (TC) and high-density lipoprotein cholesterol (HDL-C) were lower than those in the control group. Compared with the patients in stage I-II, the patients in stage III-IV had remarkably lower levels of TC and HDL-C (p<0.05). The levels of C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6) in the observation group were evidently higher than those in the control group, and they were markedly higher in patients in stage III-IV than those in stage I-II (p<0.05).
Both the metabolism disorders of blood lipid and blood glucose and inflammatory response are more obvious in ovarian cancer patients, indicating that these indicators have a place for early screening and clinical treatment of ovarian cancer.
探讨卵巢癌患者血糖、血脂及炎症指标的变化及其临床意义。
选取2018年1月至2018年12月在我院确诊并治疗的67例卵巢癌患者作为观察组。选取同期50例健康女性作为对照组。比较两组患者的血糖、血脂及炎症指标水平，分析卵巢癌患者不同临床分期上述指标的变化情况。
观察组空腹血糖和餐后2小时血糖水平均显著高于对照组，且Ⅲ-Ⅳ期患者明显高于Ⅰ-Ⅱ期患者（p<0.05）。观察组总胆固醇（TC）和高密度脂蛋白胆固醇（HDL-C）水平低于对照组。Ⅲ-Ⅳ期患者的TC和HDL-C水平明显低于Ⅰ-Ⅱ期患者（p<0.05）。观察组C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-6（IL-6）水平明显高于对照组，且Ⅲ-Ⅳ期患者明显高于Ⅰ-Ⅱ期患者（p<0.05）。
卵巢癌患者血脂和血糖代谢紊乱及炎症反应更为明显，提示这些指标在卵巢癌的早期筛查和临床治疗中具有一定价值。
