Shirai Yumiko, Morita Shunsuke, Iwata Takashi, Nakai Hiroko, Yoshikawa Mayu, Yoshida Kazuma, Iwamoto Hiroshi, Miyaji Kazuhiro, Okugawa Yoshinaga, Miki Chikao, Tanaka Koji
Department of Nutrition, Iga City General Hospital, Iga, Mie 518-0823, Japan.
Health Care and Nutritional Science Institute, Morinaga Milk Industry Co., Ltd., Zama, Kanagawa 252-8583, Japan.
Oncol Lett. 2022 Jul 12;24(3):306. doi: 10.3892/ol.2022.13426. eCollection 2022 Sep.
The present study investigated the effects of dietary supplementation combined with fish oil containing relatively low levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) on the inflammatory and nutritional status of patients with epithelial cancer. Fish oil capsules (498 mg EPA and 213 mg DHA) and dietary supplements (100 kcal and 5 g protein) were administered for 8 weeks to 20 patients with cancer and inflammation [C-reactive protein (CRP) ≥0.30 mg/dl]. Blood EPA levels increased significantly after 4 and 8 weeks, while no significant differences were observed in log-transformed (log) CRP levels, which were the major inflammatory indices in these patients. A declining trend was observed at 8 weeks after excluding 2 patients with suspected infection (P=0.06). A significant increase was observed from week 0 to week 8 for log interleukin-6 (IL-6) levels. After excluding the 2 patients with suspected infection, no significant difference was observed when comparing week 0 to week 8 for log IL-6. No deterioration in albumin or pre-albumin levels was observed. These results suggest that although suppression of acute inflammation associated with infection is difficult, intake of relatively low EPA and DHA supplements may be effective for mild chronic inflammation in patients with epithelial cancer without infection. Large-scale randomized clinical trials are required to make the final decision regarding efficacy. The study was registered in the University Hospital Medical Information Network Clinical Trials Registry (UMIN-CTR; 06/07/2018, UMIN000033309).
本研究调查了膳食补充剂联合含有相对低水平二十碳五烯酸（EPA）和二十二碳六烯酸（DHA）的鱼油对上皮癌患者炎症和营养状况的影响。向20例患有癌症且伴有炎症[C反应蛋白（CRP）≥0.30mg/dl]的患者给予鱼油胶囊（498mg EPA和213mg DHA）和膳食补充剂（100千卡热量和5克蛋白质），持续8周。4周和8周后血液中的EPA水平显著升高，而这些患者的主要炎症指标——经对数转换（log）的CRP水平未观察到显著差异。在排除2例疑似感染患者后，8周时观察到有下降趋势（P=0.06）。从第0周到第8周，log白细胞介素-6（IL-6）水平显著升高。排除2例疑似感染患者后，比较第0周和第8周的log IL-6时未观察到显著差异。未观察到白蛋白或前白蛋白水平恶化。这些结果表明，虽然抑制与感染相关的急性炎症较为困难，但摄入相对低剂量的EPA和DHA补充剂可能对无感染的上皮癌患者的轻度慢性炎症有效。需要进行大规模随机临床试验才能对疗效做出最终判定。该研究已在大学医院医学信息网络临床试验注册中心（UMIN-CTR；2018年7月6日，UMIN000033309）注册。
