从人工沉香中分离得到的四种新型联苯乙基色酮。
Four new bi-phenylethylchromones from artificial agarwood.
作者信息
Xiang Pan, Mei Wenli, Chen Huiqin, Kong Fandong, Wang Hao, Liao Ge, Zhou Liman, Dai Haofu
机构信息
Institute of Materia Medica, College of Pharmacy and Chemistry, College of Pharmacy and Chemistry, Dali University, Dali 671003, PR China.
Key Laboratory of Biology and Genetic Resources of Tropical Crops, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, PR China.
出版信息
Fitoterapia. 2017 Jul;120:61-66. doi: 10.1016/j.fitote.2017.05.012. Epub 2017 May 31.
Four new bi-phenylethylchromones (1-4) were isolated from the EtOAc extract of artificial agarwood induced by holing method originating from Aquilaria sinensis (Lour.) Gilg. The structures of new compounds were unambiguously elucidated by one- and two-dimensional NMR and HRESIMS measurements, and the absolute configuration was determined by analysis of circular dichroism (CD) spectra. All compounds were tested for acetylcholinesterase (AChE) inhibitory activity using modified Ellman's colorimetric method and α-glucosidase inhibitory activity using PNPG method. Compounds 2-4 exhibited different levels of inhibitory activity against AChE with the inhibition ratios in the range of 10-45%. However, none of the compounds was active against the α-glucosidase.
从采用打孔法诱导白木香（Aquilaria sinensis (Lour.) Gilg）生成的人工沉香的乙酸乙酯提取物中分离得到了4种新的联苯乙基色酮（1-4）。通过一维和二维核磁共振以及高分辨电喷雾电离质谱测量明确了新化合物的结构，并通过圆二色光谱分析确定了其绝对构型。使用改良的Ellman比色法测试了所有化合物对乙酰胆碱酯酶（AChE）的抑制活性，使用对硝基苯-α-D-吡喃葡萄糖苷（PNPG）法测试了其对α-葡萄糖苷酶的抑制活性。化合物2-4对AChE表现出不同程度的抑制活性，抑制率在10%-45%范围内。然而，所有化合物对α-葡萄糖苷酶均无活性。
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