Khan Safi Ullah, Ghafoor Sarah
Department of Oral Biology, University of Health Sciences, Lahore, Pakistan.
J Pak Med Assoc. 2019 Jul;69(7):1014-1017.
Physical activity has been linked with maintenance of bodily health and prevention of numerous pathologies which might arise in its absence. Physical surge renders the skeletal muscles of the body to come into action which then, besides per forming the basic functions of locomotion and maintenance of body posture, produce various proteinaceous secretions. These secretions contain skeletal muscle-released biochemical products known as myokines. More than 650 myokines have been identified and this list is increasing so rapidly that this branch of proteomics can now be designated as a 'myokinome'. This review was planned to describe the major challenges faced in myokine discovery, barriers in use of myokines as a treatment modality and the techniques utilised to overcome these scientific hurdles. Establishment of correlation of myokines with the state of health and disease can help improve clinical diagnostics and will ultimately improve the quality of life of patients.
身体活动与维持身体健康以及预防缺乏身体活动时可能出现的多种病症有关。身体应激使身体的骨骼肌开始活动，随后，骨骼肌除了执行运动和维持身体姿势的基本功能外，还会产生各种蛋白质分泌物。这些分泌物含有被称为肌动蛋白的骨骼肌释放的生化产物。现已鉴定出650多种肌动蛋白，而且这个清单增长迅速，以至于蛋白质组学的这一分支现在可以被称为“肌动蛋白组”。本综述旨在描述肌动蛋白发现过程中面临的主要挑战、将肌动蛋白用作治疗方式的障碍以及用于克服这些科学障碍的技术。建立肌动蛋白与健康和疾病状态之间的相关性有助于改善临床诊断，并最终提高患者的生活质量。
