Cellular &Molecular Metabolism Laboratory, Diabetes &Metabolism Division, Garvan Institute of Medical Research, 384 Victoria Street, Darlinghurst, New South Wales 2010, Australia.
Nat Rev Drug Discov. 2016 Oct;15(10):719-29. doi: 10.1038/nrd.2016.153. Epub 2016 Sep 12.
Exercise reduces the risk of a multitude of disorders, from metabolic disease to cancer, but the molecular mechanisms mediating the protective effects of exercise are not completely understood. The realization that skeletal muscle is an endocrine organ capable of secreting proteins termed 'myokines', which participate in tissue crosstalk, provided a critical link in the exercise-health paradigm. However, the myokine field is still emerging, and several challenges remain in the discovery and validation of myokines. This Review considers these challenges and highlights some recently identified novel myokines with the potential to be therapeutically exploited in the treatment of metabolic disease and cancer.
锻炼可降低多种疾病的风险，从代谢疾病到癌症，但运动对机体的保护作用的分子机制尚不完全清楚。骨骼肌是一种能够分泌被称为“肌肉因子”的蛋白质的内分泌器官，这些蛋白质参与组织间的通讯，这为运动-健康模式提供了一个关键联系。然而，肌肉因子领域仍在不断发展，在肌肉因子的发现和验证方面仍存在一些挑战。这篇综述考虑了这些挑战，并强调了一些最近发现的具有治疗代谢疾病和癌症潜力的新型肌肉因子。
