Exercise Medicine Research Institute, Edith Cowan University, Joondalup, WA 6027, Australia; School of Medical and Health Sciences, Edith Cowan University, Joondalup, WA 6027, Australia.
Pleural Medicine Unit, Institute for Respiratory Health, Perth, WA 6009, Australia; Medical School, Faculty of Health & Medical Sciences, University of Western Australia, Perth, WA 6009, Australia; Grupo de Pesquisa em Exercício para Populações Clínicas (GPCLIN), Universidade de Caxias do Sul, Caxias do Sul, Rio Grande do Sul 95070-560, Brazil.
J Sport Health Sci. 2024 Nov;13(6):764-779. doi: 10.1016/j.jshs.2024.04.005. Epub 2024 Apr 10.
The benefits of exercise are well known; however, many of the underlying molecular mechanisms are not fully understood. Skeletal muscle secretes myokines, which mediate muscle-organ crosstalk. Myokines regulate satellite-cell proliferation and migration, inflammatory cascade, insulin secretion, angiogenesis, fatty oxidation, and cancer suppression. To date, the effects of different exercise modes (namely, aerobic and resistance exercise) on myokine response remain to be elucidated. This is crucial considering the clinical implementation of exercise to enhance general health and wellbeing and as a medical treatment.
A systematic search was undertaken in PubMed, MEDLINE, CINAHL, Embase, SPORTDiscus, and Web of Science in April 2023. Eligible studies examining the effects of a single bout of exercise on interleukin15 (IL-15), irisin, secreted protein acidic and rich in cysteine (SPARC), oncostatin M (OSM), and decorin were included. A random-effects meta-analysis was also undertaken to quantify the magnitude of change.
Sixty-two studies were included (n = 1193). Overall, exercise appeared to induce small to large increases in myokine expression, with effects observed immediately after to 60 min post-exercise, although these were mostly not statistically significant. Both aerobic and resistance exercise resulted in changes in myokine levels, without any significant difference between training modes, and with the magnitude of change differing across myokines. Myokine levels returned to baseline levels within 180 min to 24 h post-exercise. However, owing to potential sources of heterogeneity, most changes were not statistically significant, indicating that precise conclusions cannot be drawn.
Knowledge is limited but expanding with respect to the impact of overall and specific effects of exercise on myokine expression at different time points in the systemic circulation. Further research is required to investigate the effects of different exercise modes at multiple time points on myokine response.
运动的益处众所周知；然而，许多潜在的分子机制尚未完全了解。骨骼肌分泌肌因子，介导肌肉-器官的串扰。肌因子调节卫星细胞的增殖和迁移、炎症级联反应、胰岛素分泌、血管生成、脂肪氧化和癌症抑制。迄今为止，不同运动方式（即有氧运动和抗阻运动）对肌因子反应的影响仍有待阐明。考虑到运动对增强整体健康和幸福感的临床应用，以及作为一种治疗方法，这一点至关重要。
我们于 2023 年 4 月在 PubMed、MEDLINE、CINAHL、Embase、SPORTDiscus 和 Web of Science 中进行了系统检索。纳入了研究单次运动对白细胞介素 15（IL-15）、鸢尾素、富含半胱氨酸的酸性分泌蛋白（SPARC）、肿瘤坏死因子（OSM）和核心蛋白聚糖（decorin）影响的研究。还进行了随机效应荟萃分析来量化变化幅度。
共纳入 62 项研究（n=1193）。总体而言，运动似乎会引起肌因子表达的小到大幅度增加，运动后即刻至 60 分钟即可观察到这些变化，尽管这些变化大多没有统计学意义。有氧运动和抗阻运动都导致肌因子水平的变化，两种训练模式之间没有差异，而且不同肌因子的变化幅度也不同。运动后 180 分钟至 24 小时内，肌因子水平恢复到基线水平。然而，由于潜在的异质性来源，大多数变化没有统计学意义，这表明不能得出确切的结论。
关于运动对系统循环中不同时间点肌因子表达的整体和特定影响的知识是有限的，但正在不断扩展。需要进一步的研究来调查不同运动方式在多个时间点对肌因子反应的影响。
Zotero 插件
