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姜黄素凝胶与非丁香酚牙周敷料对慢性牙周炎患者牙周翻瓣术后组织反应、早期伤口愈合及疼痛评估影响的比较

Comparison of effect of curcumin gel and noneugenol periodontal dressing in tissue response, early wound healing, and pain assessment following periodontal flap surgery in chronic periodontitis patients.

作者信息

Meghana M Venkata Sai, Deshmukh Jeevanand, Devarathanamma M V, Asif K, Jyothi L, Sindhura H

机构信息

Department of Periodontology, Navodaya Dental College and Hospital, Raichur, Karnataka, India.

出版信息

J Indian Soc Periodontol. 2020 Jan-Feb;24(1):54-59. doi: 10.4103/jisp.jisp_105_19. Epub 2020 Jan 2.

DOI:10.4103/jisp.jisp_105_19
PMID:31983846
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6961441/
Abstract

BACKGROUND

The study was designed taking into consideration the drawbacks of periodontal dressing and healing properties of curcumin. The aim was to assess and compare the effect of Curcumin gel (Curenext) and noneugenol periodontal dressing (Coe pak) on tissue response, wound healing in the early stages, and pain post periodontal flap surgery in patients diagnosed with chronic periodontitis.

MATERIALS AND METHODS

Twenty patients requiring periodontal flap surgery were allotted to two groups at random, one receiving periodontal dressing and the other receiving curcumin for this cross over split-mouth study. Flap surgeries were performed on 2 quadrants with 3 weeks' interval. After suture removal, postoperative sites were assessed for tissue response (tissue color [TC] and tissue edema [TE]) and early wound healing as primary outcomes of the study. The secondary outcome was pain assessment and the number of analgesics taken by the individuals.

RESULTS

The two groups showed no significant differences with respect to tissue response, early wound healing, and pain perception. Curcumin group consumed lesser number of analgesics as compared to the one with periodontal dressing.

CONCLUSION

It was confirmed that periodontal dressing and curcumin are effective in reducing the TE, normalizing the TC, enhancing the wound healing and reducing the pain perception. Curcumin can thus be used as an alternative to periodontal dressing.

摘要

背景

本研究的设计考虑了牙周敷料的缺点以及姜黄素的愈合特性。目的是评估和比较姜黄素凝胶(Curenext)和非丁香酚牙周敷料(Coe pak)对诊断为慢性牙周炎患者的组织反应、早期伤口愈合以及牙周翻瓣手术后疼痛的影响。

材料与方法

将20例需要进行牙周翻瓣手术的患者随机分为两组,一组接受牙周敷料,另一组接受姜黄素,进行这项交叉双盲研究。在两个象限进行翻瓣手术,间隔3周。拆线后,评估术后部位的组织反应(组织颜色[TC]和组织水肿[TE])以及早期伤口愈合情况,作为本研究的主要结果。次要结果是疼痛评估以及个体服用的镇痛药数量。

结果

两组在组织反应、早期伤口愈合和疼痛感知方面无显著差异。与使用牙周敷料的组相比,姜黄素组服用的镇痛药数量较少。

结论

证实牙周敷料和姜黄素在减轻组织水肿、使组织颜色正常化、促进伤口愈合和减轻疼痛感知方面有效。因此,姜黄素可作为牙周敷料的替代品。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/6961441/9a5e4ac53f19/JISP-24-54-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/6961441/9a5e4ac53f19/JISP-24-54-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/265c/6961441/9a5e4ac53f19/JISP-24-54-g003.jpg

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