Aggarwal Kanika, Gupta Shipra, Sood Shaveta, Bhardwaj Sonia Bhonchal, Prashar Savita, Jain Ashish
Department of Periodontology, Dr. Harvansh Singh Judge Institute of Dental Sciences and Hospital, Panjab University, Chandigarh, India.
Unit of Periodontics, Oral Health Sciences Centre, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
J Indian Soc Periodontol. 2021 Nov-Dec;25(6):504-509. doi: 10.4103/jisp.jisp_17_21. Epub 2021 Nov 1.
Periodontal dressings are used for wound protection and patient comfort. Nano-silver particles have the ability to promote wound healing through anti-inflammatory properties. Hence, the present study aims to evaluate early wound healing parameters following periodontal surgery using nano-crystalline silver membrane as periodontal dressing.
Forty-two systemically healthy patients diagnosed with chronic periodontitis indicated for periodontal flap surgery were enrolled for the present study. Post surgery, the patients were randomly allocated to either a nano-crystalline silver dressing (Acticoat™) group (test group) or only the noneugenol dressing group (control group). Plaque index (PI) and wound healing index were recorded at the 7- and 14-day postsurgery. The microbiological analysis and vascular endothelial growth factor (VEGF) levels were evaluated at baseline and 7-day postsurgery.
The healing index was significantly higher in the test group as compared to the control group at days 7 and 14 ( < 0.001; < 0.001). The colony-forming units/ml count of bacteria were significantly reduced postsurgery in the test group ( = 0.019). VEGF levels increased significantly 7-day postsurgery in the test group ( = 0.001). There was no statistically significant difference in the PI on the 7-day postsurgery between the two groups ( = 0.173).
The results of the study revealed that silver can be used as a potent periodontal dressing ingredient that can decrease the microbial colonization beneath the pack and promote faster healing postsurgery due to its antimicrobial activity.
牙周敷料用于伤口保护并提高患者舒适度。纳米银颗粒具有通过抗炎特性促进伤口愈合的能力。因此，本研究旨在评估使用纳米晶银膜作为牙周敷料进行牙周手术后的早期伤口愈合参数。
本研究纳入了42名被诊断为慢性牙周炎且需进行牙周瓣手术的全身健康患者。术后，患者被随机分为纳米晶银敷料（Acticoat™）组（试验组）或仅使用非丁香酚敷料组（对照组）。在术后第7天和第14天记录菌斑指数（PI）和伤口愈合指数。在基线和术后第7天评估微生物分析和血管内皮生长因子（VEGF）水平。
在第7天和第14天，试验组的愈合指数显著高于对照组（<0.001；<0.001）。试验组术后细菌的菌落形成单位/毫升计数显著降低（=0.019）。试验组术后第7天VEGF水平显著升高（=0.001）。两组术后第7天的PI无统计学显著差异（=0.173）。
研究结果表明，银可作为一种有效的牙周敷料成分，由于其抗菌活性，可减少敷料下的微生物定植并促进术后更快愈合。
