新型抗真菌抗生素二十八元菌素A和B。I. 分类学、发酵与分离、理化性质及生物活性。
Novel antifungal antibiotics octacosamicins A and B. I. Taxonomy, fermentation and isolation, physico-chemical properties and biological activities.
作者信息
Dobashi K, Matsuda N, Hamada M, Naganawa H, Takita T, Takeuchi T
机构信息
Institute of Microbial Chemistry, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1988 Nov;41(11):1525-32. doi: 10.7164/antibiotics.41.1525.
PMID:3198488
Abstract
Two antifungal antibiotics octacosamicins A and B were isolated from the culture broth of a strain of actinomycetes, which was identified as a strain of Amycolatopsis. These antibiotics were isolated by resin adsorption and purified by column chromatography and preparative HPLC. Both antibiotics were found to be new substances from their physico-chemical properties. They showed broad antifungal spectra.
摘要
从一株放线菌的培养液中分离出两种抗真菌抗生素二十八环霉素A和B，该放线菌被鉴定为拟无枝酸菌属的一个菌株。这些抗生素通过树脂吸附进行分离，并通过柱色谱和制备型高效液相色谱进行纯化。根据其物理化学性质，这两种抗生素均被发现是新物质。它们显示出广泛的抗真菌谱。
Zotero 插件