在半岛地区，由青霉菌产生的新型抗真菌抗生素。生产、分离、理化性质及生物学特性。
Atpenins, new antifungal antibiotics produced by Penicillium sp. Production, isolation, physico-chemical and biological properties.
作者信息
Omura S, Tomoda H, Kimura K, Zhen D Z, Kumagai H, Igarashi K, Imamura N, Takahashi Y, Tanaka Y, Iwai Y
机构信息
Kitasato Institute, Tokyo, Japan.
出版信息
J Antibiot (Tokyo). 1988 Dec;41(12):1769-73. doi: 10.7164/antibiotics.41.1769.
Penicillium sp. FO-125, a soil isolate, was found to produce a new antifungal antibiotic complex named atpenin. Three components A4, A5 and B were isolated from the fermentation broth of the producing strain by solvent extraction, silica gel column chromatography and HPLC. The molecular formula of atpenins A4, A5 and B were determined to be C15H22NO5Cl, C15H21NO5Cl2 and C15H23NO5, respectively, on the basis of high resolution electron impact mass spectrometry and elemental analysis. They are active against filamentous fungi, especially, Trichophyton sp.
青霉菌株FO-125是从土壤中分离得到的，它能产生一种名为atpenin的新型抗真菌抗生素复合物。通过溶剂萃取、硅胶柱色谱和高效液相色谱法，从该生产菌株的发酵液中分离出了三种成分A4、A5和B。基于高分辨率电子轰击质谱和元素分析，确定atpenins A4、A5和B的分子式分别为C15H22NO5Cl、C15H21NO5Cl2和C15H23NO5。它们对丝状真菌具有活性，尤其是对毛癣菌属。
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