Department of Clinical Pathology, Poznań University of Medical Sciences.
Pathology Department, University Hospital of Lord's Transfiguration, Partner of Karol Marcinkowski University of Medical Sciences, Poznań, Poland.
Am J Surg Pathol. 2020 Jun;44(6):799-804. doi: 10.1097/PAS.0000000000001436.
Myogenic differentiation (MD) has been claimed to be a poor prognostic factor in dedifferentiated liposarcoma (DDLPS). To validate this, the prognostic significance of MD in a uniformly treated cohort of DDLPS was assessed. A cohort of patients that have been uniformly treated at one institution for DDLPS of the retroperitoneum and pelvis were stained with smooth muscle actin (SMA) and desmin and semiquantitatively scored for staining focality and strength. Clinical and survival data was collected, and the prognostic significance of MD was evaluated. A total of 50 patients with uniformly treated DDLPS were evaluated. SMA (P=0.052) and a combined score of MD (SMA+desmin) showed a statistically significant decrease in 5-year disease-free survival (P=0.002) in univariate analysis and in multivariate testing combined MD trended toward significance (P=0.052). Combined MD was associated with a decreased OS in multivariate analysis (P=0.004). In a uniformly treated cohort of DDLPS stained for myogenic markers, a combined myogenic score was associated with poor overall survival in multivariate analysis. However, the difference in groups was slight and the clinical application is limited.
成肌分化（MD）被认为是去分化脂肪肉瘤（DDLPS）的预后不良因素。为了验证这一点，评估了 MD 在经过统一治疗的 DDLPS 队列中的预后意义。对一组在一个机构接受后腹膜和骨盆 DDLPS 统一治疗的患者进行了平滑肌肌动蛋白（SMA）和结蛋白染色，并对染色焦点和强度进行了半定量评分。收集了临床和生存数据，并评估了 MD 的预后意义。共评估了 50 例经统一治疗的 DDLPS 患者。SMA（P=0.052）和 MD 的综合评分（SMA+结蛋白）在单因素分析中显示出 5 年无病生存率（DFS）的统计学显著降低（P=0.002），在多因素检测中，MD 综合评分也有显著趋势（P=0.052）。多因素分析显示，MD 与 OS 降低相关（P=0.004）。在经过肌源性标志物染色的统一治疗的 DDLPS 队列中，多因素分析显示综合肌源性评分与总生存不良相关。然而，组间差异很小，临床应用有限。
