Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America.
Republican Centre of Population Protection from Tuberculosis, Dushanbe, Tajikistan.
PLoS One. 2020 Jan 27;15(1):e0228216. doi: 10.1371/journal.pone.0228216. eCollection 2020.
Over the years, technological and process innovations enabled active case finding (ACF) programs to expand their capacities and scope to have evolved to close gaps in missing TB patients globally. However, with increased ACF program's operational complexity and a need for significant resource commitments, a comprehensive, transparent, and standardized approach in evaluating costs of ACF programs is needed to properly determine costs and value of ACF programs.
Based on reviews of program activity and financial reports, multiple interviews with program managers of two TB REACH funded ACF programs deployed in Cambodia and Tajikistan, we first identified common program components, which formed the basis of the cost data collection, analysis, reporting framework. Within each program component and sub-activity group, cost data were collected and organized by relevant resource types (human resource, capital, recurrent, and overhead costs). Total shared, indirect and overhead costs were apportioned into each activity category based on direct human resource contribution (e.g. a number of staff and their relative level of effort dedicated to each program component). Capital assets were assessed specific to program components and were annualized based on their expected useful life and a 3% discount rate. All costs were assessed based on the service provider perspective and expressed in 2015 USD.
Over the two program years (April 2013 to December 2015), the Cambodia and Tajikistan ACF programs cumulated a total cost of $336,951 and $771,429 to screen 68,846 and 1,980,516 target population, bacteriologically test 4,589 and 19,764 presumptive TB, diagnose 731 and 2,246 TB patients in the respective programs. Recurrent costs were the largest cost components (54% and 34%) of the total costs for the respective programs and Xpert MTB/RIF (Xpert) testing incurred largest program component/activity cost for both programs. Cost per screening was $0.63 and $0.10 and cost per Xpert test was $25 and $18; Cost per TB case detected (Xpert) was $373 and $343 in Cambodia and Tajikistan.
Results from two contextually and programmatically different multi-component ACF programs demonstrate that our tool is fully capable of comprehensively and transparently evaluating and comparing costs of various ACF programs.
多年来,技术和流程创新使主动病例发现(ACF)项目能够扩大其能力和范围,从而在全球范围内缩小结核病患者的漏诊差距。然而,随着 ACF 项目运营复杂性的增加和对大量资源承诺的需求,需要采用全面、透明和标准化的方法来评估 ACF 项目的成本,以便正确确定 ACF 项目的成本和价值。
根据对项目活动和财务报告的审查,以及对柬埔寨和塔吉克斯坦两个 TB REACH 资助的 ACF 项目的项目管理人员的多次访谈,我们首先确定了常见的项目组成部分,这些部分构成了成本数据收集、分析、报告框架的基础。在每个项目组成部分和子活动组内,按相关资源类型(人力资源、资本、经常性和间接成本)收集和组织成本数据。根据直接人力资源贡献(例如,致力于每个项目组成部分的员工人数及其相对工作努力程度),将总共有、间接和间接成本分配到每个活动类别中。根据项目组成部分对资本资产进行评估,并根据其预期使用寿命和 3%的折扣率进行年化处理。所有成本均从服务提供商的角度进行评估,并以 2015 年美元表示。
在两个项目年度(2013 年 4 月至 2015 年 12 月)期间,柬埔寨和塔吉克斯坦的 ACF 项目筛查了 68846 人和 1980516 人,累计总成本分别为 336951 美元和 771429 美元,对 4589 人和 19764 名疑似结核病患者进行了细菌学检测,分别诊断出 731 人和 2246 名结核病患者。经常性成本是两个项目总成本的最大组成部分(分别为 54%和 34%),Xpert MTB/RIF(Xpert)检测是两个项目最大的项目组成部分/活动成本。筛查成本分别为 0.63 美元和 0.10 美元,Xpert 检测成本分别为 25 美元和 18 美元;在柬埔寨和塔吉克斯坦,每发现一例结核病病例(Xpert)的成本分别为 373 美元和 343 美元。
来自两个背景和方案不同的多组件 ACF 项目的结果表明,我们的工具完全能够全面、透明地评估和比较各种 ACF 项目的成本。