Sattar Tayyaba, Nazir Iqra, Jabbar Mehreen, Malik Javaria, Afzal Saba, Hanif Sana, Mosaddad Seyed Ali, Hussain Ahmed, Tebyaniyan Hamid
University Institute of Physical Therapy, The University of Lahore, Lahore, 54000, Pakistan.
Faculty of Pharmacy, The University of Lahore, Lahore, 54770, Pakistan.
Oncol Res. 2025 Apr 18;33(5):1019-1032. doi: 10.32604/or.2025.060601. eCollection 2025.
Head and neck cancers (HNC) account for a significant global health burden, with increasing incidence rates and complex treatment requirements. Traditional diagnostic and therapeutic approaches, while effective, often result in substantial morbidity and limitations in personalized care. This review provides a comprehensive overview of the latest innovations in diagnostics and therapeutic strategies for HNC from 2015 to 2024.
A review of literature focused on pe-reviewed journals, clinical trial databases, and oncology conference proceedings. Key areas include molecular diagnostics, imaging technologies, minimally invasive surgeries, and innovative therapeutic strategies.
Technologies like liquid biopsy next-generation sequencing (NGS) have greatly improved diagnostic accuracy and personalization in HNC care. These advancements have improved survival rates and enhanced patients' quality of life. Personalized therapeutic approaches, including immune checkpoint inhibitors, precision radiation therapy, and surgery, have led to enhanced treatment efficacy while reducing side effects. The integration of AI and machine learning into diagnostics and treatment planning shows promise in optimizing clinical decision-making and predicting treatment outcomes.
The current innovations in diagnostics and therapeutics are reshaping the management of head and neck cancer, offering more tailored and effective approaches to care. Overall, the continuous integration of these innovations in clinical practice is reshaping HNC treatment and improving patient outcomes and survival rates. Future research should focus on further refining these technologies, addressing challenges related to accessibility, and exploring their long-term clinical benefits in diverse patient populations.
头颈癌（HNC）在全球造成了重大的健康负担，发病率不断上升，治疗需求复杂。传统的诊断和治疗方法虽然有效，但往往会导致严重的发病率，并在个性化医疗方面存在局限性。本综述全面概述了2015年至2024年头颈癌诊断和治疗策略的最新创新。
对同行评审期刊、临床试验数据库和肿瘤学会议论文集的文献进行综述。关键领域包括分子诊断、成像技术、微创手术和创新治疗策略。
液体活检下一代测序（NGS）等技术极大地提高了头颈癌护理中的诊断准确性和个性化程度。这些进展提高了生存率，改善了患者的生活质量。个性化治疗方法，包括免疫检查点抑制剂、精确放射治疗和手术，在提高治疗效果的同时减少了副作用。将人工智能和机器学习整合到诊断和治疗计划中，在优化临床决策和预测治疗结果方面显示出前景。
目前诊断和治疗方面的创新正在重塑头颈癌的管理方式，提供更具针对性和有效性的护理方法。总体而言，这些创新在临床实践中的持续整合正在重塑头颈癌治疗，并改善患者的治疗效果和生存率。未来的研究应专注于进一步完善这些技术，解决可及性相关的挑战，并探索它们在不同患者群体中的长期临床益处。
