Tourtellotte W W, Baumhefner R W, Syndulko K, Shapshak P, Osborne M, Rubinshtein G, Newton L, Ellison G, Myers L, Rosario I
Neurology Service, VAMC West Los Angeles, Wadsworth Division, CA 90073.
J Neuroimmunol. 1988 Dec;20(2-3):217-27. doi: 10.1016/0165-5728(88)90163-4.
Much progress has been made, especially in the last two decades, in laboratory aids to diagnosis and to follow the course of patients with multiple sclerosis (MS). The cerebrospinal fluid (CSF) profile indicative of MS, though not pathognomonic of MS, is present in almost every case of clinical definite MS in a chronic progressive phase (probably also true for early MS). The cardinal aspect of the profile is intra-blood-brain barrier (BBB) IgG synthesis which can be qualitatively detected by determining unique CSF oligoclonal IgG bands and quantitated by rate formula, mg/day. We believe that intra-BBB IgG synthesis is caused by a persistent antigen, most likely a virus, possibly measles. A number of issues about the profile are proposed and opportunities are presented to resolve them.
在用于诊断和跟踪多发性硬化症（MS）患者病程的实验室辅助手段方面已经取得了很大进展，尤其是在过去二十年中。表明MS的脑脊液（CSF）特征，虽然不是MS所特有的，但几乎出现在每一例处于慢性进展期的临床确诊MS病例中（早期MS可能也是如此）。该特征的主要方面是血脑屏障（BBB）内IgG合成，可通过测定独特的脑脊液寡克隆IgG带进行定性检测，并通过速率公式（毫克/天）进行定量。我们认为BBB内IgG合成是由一种持续存在的抗原引起的，最有可能是一种病毒，可能是麻疹病毒。提出了一些关于该特征的问题，并提供了解决这些问题的机会。
