Health Research Institute La Fe, Valencia, Spain.
Division of Neurology, University and Polytechnic Hospital La Fe, Valencia, Spain.
Clin Chim Acta. 2020 Apr;503:163-168. doi: 10.1016/j.cca.2020.01.019. Epub 2020 Jan 24.
Neurodegenerative diseases are a great concern because of aging worldwide population. Despite substantial effort to advance our understanding of the etiology and potential treatment of neurodegeneration, there remains a paucity of information with respect to this complex disease process. Interestingly, stress has been implicated among the potential mechanisms implicated in neurodegenerative pathology. Given the increase in chronic stress in modern society, this premise warrants further investigation. The aim of this review is to evaluate the influence of stress on neurodegeneration, the effect of neurodegenerative diseases diagnosis on stress, and therapeutic strategies for neurodegenerative diseases with a special focus on stress reduction. Neurodegenerative disorders such as Alzheimer's, Parkinson's and Huntington's Disease showed an acceleration in disease progression and a worsening of symptoms under stress. Some therapies (e.g., yoga, meditation) focused on reducing stress showed beneficial effects against neurodegeneration. Nevertheless, more studies are necessary in order to completely understand the implications of stress in neurodegeneration and the usefulness of stress reduction in the treatment thereof.
神经退行性疾病是一个全球性的问题，因为全球人口老龄化。尽管我们做出了巨大的努力来加深对神经退行性疾病的病因和潜在治疗方法的理解，但对于这种复杂的疾病过程，我们仍然知之甚少。有趣的是，压力被认为是神经退行性病理的潜在机制之一。鉴于现代社会慢性压力的增加，这一前提值得进一步研究。本综述的目的是评估压力对神经退行性变的影响、神经退行性疾病诊断对压力的影响，以及针对神经退行性疾病的治疗策略，特别关注减轻压力。阿尔茨海默病、帕金森病和亨廷顿病等神经退行性疾病在压力下表现出疾病进展加速和症状恶化。一些专注于减轻压力的疗法（如瑜伽、冥想）对神经退行性变表现出有益的影响。然而，为了完全了解压力对神经退行性变的影响以及减轻压力在治疗中的作用，还需要更多的研究。
