Ministry-of-Education Key Laboratory for the Green Preparation and Application of Functional Materials, Hubei Key Laboratory of Polymer Materials, School of Materials Science & Engineering , Hubei University , Wuhan 430062 , China.
School of Materials Science & Engineering, the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of China , Tianjin University , Tianjin 300072 , China.
ACS Nano. 2020 Feb 25;14(2):2077-2089. doi: 10.1021/acsnano.9b08686. Epub 2020 Jan 31.
Periprosthetic infection is considered the main cause of implant failure, which is expected to be solved by fabricating an antibacterial coating on the surface of the implant. Nevertheless, systemic antibiotic treatment still represents the mainstream method for preventing infection, and few antibacterial coatings are applied clinically. This is because the externally introduced traditional antibacterial coatings suffer from the risk of invalidation and tissue toxicity induced by the consumption of antibacterial agents, degradation, and shedding. In this work, we proposed a rapid photo-sonotherapy by creating an oxygen deficiency on a titanium (Ti) implant through sulfur (S)-doping (Ti-S-TiO), which endowed the implants with great sonodynamic and photothermal ability. Without introducing an external antibacterial coating, it reached a high antibacterial efficiency of 99.995% against under 15 min near-infrared light and ultrasound treatments. Furthermore, bone infection was successfully treated after combination treatments, and improved osseointegration was observed. Importantly, the S-doped Ti implant immersed in water for 6 months showed an unchanged structure and properties, suggesting that the Ti implant with intrinsic modification showed stable antibacterial performance under exogenous stimuli with a high antibacterial performance . This photo-sonotherapy based on sulfur doping is also promising for cancer therapy with biosafety.
假体周围感染被认为是导致植入物失败的主要原因，人们期望通过在植入物表面制造抗菌涂层来解决这个问题。然而，全身抗生素治疗仍然是预防感染的主流方法，很少有抗菌涂层应用于临床。这是因为外部引入的传统抗菌涂层会因抗菌剂的消耗、降解和脱落而导致失效和组织毒性的风险。在这项工作中，我们通过在钛（Ti）植入物中掺杂硫（S）来创建缺氧（Ti-S-TiO），提出了一种快速光声疗法，赋予了植入物强大的声动力和光热能力。无需引入外部抗菌涂层，在 15 分钟的近红外光和超声治疗下，对 达到了 99.995%的高效抗菌率。此外，联合治疗成功治疗了骨感染，并观察到了骨整合的改善。重要的是，浸泡在水中 6 个月的 S 掺杂 Ti 植入物显示出结构和性能不变，这表明具有内在改性的 Ti 植入物在外源刺激下具有稳定的抗菌性能，具有高抗菌性能。基于硫掺杂的这种光声疗法也有望具有生物安全性的癌症治疗。
