Public Experimental Research Center of Xuzhou Medical University, Xuzhou, Jiangsu Province, 221004, People's Republic of China.
Department of Neurology, the Affiliated Xuzhou Municipal Hospital of Xuzhou Medical University, Xuzhou No. 1 People's Hospital, Xuzhou, Jiangsu Province, 221100, People's Republic of China.
Int J Nanomedicine. 2024 Aug 24;19:8681-8694. doi: 10.2147/IJN.S475973. eCollection 2024.
Developing novel multimodal nanomaterials-based anticancer agents to meet complex clinical demands is an urgent challenge. This study presents a novel uniform hollow S-doped NiCuFe Prussian blue analogue (NiCuFe-S) with satisfactory size and properties as anticancer agents for efficient cervical cancer therapy using a simple and environmentally friendly procedure.
The formation mechanism and the reason for enhanced performance of NiCuFe-S were characterized and discussed by diverse spectroscopic and microscopic methods. Moreover, to demonstrate the anti-cancer ability of NiCuFe-S, in vitro and in vivo experiments were carried out.
Compared to the non-doped NiCuFe, the NiCuFe-S exhibited significantly enhanced photothermal and catalytic activity attributed to the electronic bandgap-narrowing effect and the increased electron circuit paths resulting from S doping. The hollow structure of NiCuFe-S facilitated the loading of small-molecule drugs, such as doxorubicin (DOX), transforming it into a multimodal nanoplatform for cervical cancer treatment. In vitro and in vivo experiments proved the potential of the NiCuFe-S nanotheranostic agent for chemodynamic therapy (CDT), photothermal therapy (PTT), and chemotherapy for cervical cancer.
This research not only overcomes inherent limitations but also significantly broadens the applications of Prussian blue analogues in biomedicine.
开发新型多模态纳米材料抗癌剂以满足复杂的临床需求是一个紧迫的挑战。本研究提出了一种新型均匀的空心 S 掺杂 NiCuFe 普鲁士蓝类似物（NiCuFe-S），其尺寸和性能令人满意，可通过简单且环保的方法用于高效宫颈癌治疗。
通过多种光谱和显微镜方法对 NiCuFe-S 的形成机制和性能增强的原因进行了表征和讨论。此外，为了证明 NiCuFe-S 的抗癌能力，进行了体外和体内实验。
与未掺杂的 NiCuFe 相比，NiCuFe-S 表现出明显增强的光热和催化活性，这归因于电子带隙变窄效应和 S 掺杂导致的增加的电子电路路径。NiCuFe-S 的空心结构有利于装载小分子药物，如阿霉素（DOX），将其转化为用于宫颈癌治疗的多模态纳米平台。体外和体内实验证明了 NiCuFe-S 纳米治疗剂在化学动力学治疗（CDT）、光热治疗（PTT）和宫颈癌化疗方面的潜力。
这项研究不仅克服了固有限制，还显著拓宽了普鲁士蓝类似物在生物医学中的应用。
