白细胞介素-10 -1082G > A 多态性与复发性妊娠丢失易感性相关的累积证据：系统评价和荟萃分析。
Cumulative Evidence for Association of IL-10 -1082G > A Polymorphism with Susceptibility to Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis.
机构信息
Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Lorestan, Iran.
Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
出版信息
Fetal Pediatr Pathol. 2021 Oct;40(5):471-485. doi: 10.1080/15513815.2020.1716903. Epub 2020 Jan 28.
The IL-10 -1082 G > A polymorphism has been reported to be associated with a risk of recurrent pregnancy loss (RPL) with inconsistent results. Thus, to clarify the effect of the polymorphism on the susceptibility to RPL, a meta-analysis was performed. A systematic literature search in PubMed, Web of Science, Scopus and SciELO was performed to identify the relevant studies published up to December 20, 2019, and related information was extracted. A total of 17 case-control studies with 3,224 RPL cases and 3,295 controls were selected. Pooled data revealed that IL-10 -1082 G > A polymorphism was significantly associated with risk of RPL in the global population. Moreover, subgroup analysis indicated a significant association in Caucasians, but not in Asian or mixed populations. Our pooled data highlights that IL-10 -1082 G > A polymorphism is a risk factor for RPL susceptibility in the global population, especially in Caucasians.
IL-10 -1082 G > A 多态性与复发性妊娠丢失（RPL）的风险相关，但结果不一致。因此，为了阐明该多态性对 RPL 易感性的影响，进行了荟萃分析。在 PubMed、Web of Science、Scopus 和 SciELO 中进行了系统的文献检索，以确定截至 2019 年 12 月 20 日发表的相关研究，并提取了相关信息。共选择了 17 项病例对照研究，包括 3224 例 RPL 病例和 3295 例对照。汇总数据显示，IL-10 -1082 G > A 多态性与全球人群 RPL 的风险显著相关。此外，亚组分析表明，在白种人群中存在显著相关性，但在亚洲人群或混合人群中不存在。我们的汇总数据强调，IL-10 -1082 G > A 多态性是全球人群 RPL 易感性的一个危险因素，尤其是在白种人群中。
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