Department of Obstetrics and Gynecology, Lorestan University of Medical Sciences, Lorestan, Iran.
Department of Obstetrics and Gynecology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fetal Pediatr Pathol. 2021 Oct;40(5):471-485. doi: 10.1080/15513815.2020.1716903. Epub 2020 Jan 28.
The IL-10 -1082 G > A polymorphism has been reported to be associated with a risk of recurrent pregnancy loss (RPL) with inconsistent results. Thus, to clarify the effect of the polymorphism on the susceptibility to RPL, a meta-analysis was performed. A systematic literature search in PubMed, Web of Science, Scopus and SciELO was performed to identify the relevant studies published up to December 20, 2019, and related information was extracted. A total of 17 case-control studies with 3,224 RPL cases and 3,295 controls were selected. Pooled data revealed that IL-10 -1082 G > A polymorphism was significantly associated with risk of RPL in the global population. Moreover, subgroup analysis indicated a significant association in Caucasians, but not in Asian or mixed populations. Our pooled data highlights that IL-10 -1082 G > A polymorphism is a risk factor for RPL susceptibility in the global population, especially in Caucasians.
IL-10 -1082 G > A 多态性与复发性妊娠丢失（RPL）的风险相关，但结果不一致。因此，为了阐明该多态性对 RPL 易感性的影响，进行了荟萃分析。在 PubMed、Web of Science、Scopus 和 SciELO 中进行了系统的文献检索，以确定截至 2019 年 12 月 20 日发表的相关研究，并提取了相关信息。共选择了 17 项病例对照研究，包括 3224 例 RPL 病例和 3295 例对照。汇总数据显示，IL-10 -1082 G > A 多态性与全球人群 RPL 的风险显著相关。此外，亚组分析表明，在白种人群中存在显著相关性，但在亚洲人群或混合人群中不存在。我们的汇总数据强调，IL-10 -1082 G > A 多态性是全球人群 RPL 易感性的一个危险因素，尤其是在白种人群中。
