Neuroscience Graduate Program, University of Colorado Anschutz Medical Campus, Aurora, United States.
Department of Cell and Developmental Biology, University of Colorado Anschutz Medical Campus, Aurora, United States.
Elife. 2020 Jan 28;9:e52583. doi: 10.7554/eLife.52583.
Local field potential oscillations reflect temporally coordinated neuronal ensembles-coupling distant brain regions, gating processing windows, and providing a reference for spike timing-based codes. In phase amplitude coupling (PAC), the amplitude of the envelope of a faster oscillation is larger within a phase window of a slower carrier wave. Here, we characterized PAC, and the related theta phase-referenced high gamma and beta power (PRP), in the olfactory bulb of mice learning to discriminate odorants. PAC changes throughout learning, and odorant-elicited changes in PRP increase for rewarded and decrease for unrewarded odorants. Contextual odorant identity (is the odorant rewarded?) can be decoded from peak PRP in animals proficient in odorant discrimination, but not in naïve mice. As the animal learns to discriminate the odorants the dimensionality of PRP decreases. Therefore, modulation of phase-referenced chunking of information in the course of learning plays a role in early sensory processing in olfaction.
局部场电位振荡反映了时间上协调一致的神经元集合——连接远距离脑区、控制处理窗口，并为基于尖峰时间的编码提供参考。在相位-振幅耦合（PAC）中，较快振荡的包络的振幅在较慢载波的相位窗口内较大。在这里，我们描述了在学习区分气味的小鼠嗅球中的 PAC 以及相关的θ相位参考的高γ和β功率（PRP）。PAC 在整个学习过程中发生变化，并且对于奖励和不奖励的气味，PRP 的气味诱发变化增加和减少。在熟练区分气味的动物中，可以从峰值 PRP 解码出与上下文相关的气味身份（气味是否受到奖励？），但在未接受训练的小鼠中则不能。随着动物学会区分气味，PRP 的维度减少。因此，在学习过程中，信息的相位参考分块的调制在嗅觉的早期感觉处理中起着作用。
