Department of Biological Sciences, University of Denver, Denver, CO 80208, USA.
Department of Biological Sciences, University of Denver, Denver, CO 80208, USA.
Dev Cell. 2020 Jan 27;52(2):135-136. doi: 10.1016/j.devcel.2020.01.001.
Pulsed actomyosin contractions drive morphogenetic processes, but how cyclic frequencies and amplitudes of contractions are tuned to achieve processive shrinking of cell surfaces remains unclear. In this issue of Developmental Cell, Cavanaugh et al. (2020) use optogenetics and biophysical modeling to demonstrate how cells respond to different oscillatory force profiles.
脉冲肌球蛋白收缩驱动形态发生过程，但细胞表面连续收缩如何通过调节收缩的循环频率和幅度来实现仍不清楚。在本期《发育细胞》中，Cavanaugh 等人（2020 年）利用光遗传学和生物物理建模来证明细胞如何响应不同的振荡力模式。
