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个人基因组时代的基因组学教育:学术、专业和公众的考虑。

Genomics Education in the Era of Personal Genomics: Academic, Professional, and Public Considerations.

机构信息

Department of Microbiology and Molecular Biology, 4007 Life Sciences Building, 701 East University Parkway, Brigham Young University, Provo, UT 84602, USA.

出版信息

Int J Mol Sci. 2020 Jan 24;21(3):768. doi: 10.3390/ijms21030768.

Abstract

Since the completion of the Human Genome Project in 2003, genomic sequencing has become a prominent tool used by diverse disciplines in modern science. In the past 20 years, the cost of genomic sequencing has decreased exponentially, making it affordable and accessible. Bioinformatic and biological studies have produced significant scientific breakthroughs using the wealth of genomic information now available. Alongside the scientific benefit of genomics, companies offer direct-to-consumer genetic testing which provide health, trait, and ancestry information to the public. A key area that must be addressed is education about what conclusions can be made from this genomic information and integrating genomic education with foundational genetic principles already taught in academic settings. The promise of personal genomics providing disease treatment is exciting, but many challenges remain to validate genomic predictions and diagnostic correlations. Ethical and societal concerns must also be addressed regarding how personal genomic information is used. This genomics revolution provides a powerful opportunity to educate students, clinicians, and the public on scientific and ethical issues in a personal way to increase learning. In this review, we discuss the influence of personal genomics in society and focus on the importance and benefits of genomics education in the classroom, clinics, and the public and explore the potential consequences of personal genomic education.

摘要

自 2003 年人类基因组计划完成以来,基因组测序已成为现代科学中不同学科广泛使用的重要工具。在过去的 20 年中,基因组测序的成本呈指数级下降,使其变得负担得起且易于获得。生物信息学和生物学研究利用现在可用的丰富基因组信息取得了重大的科学突破。除了基因组学的科学益处外,公司还向公众提供直接面向消费者的基因检测,提供健康、特征和祖先信息。一个必须解决的关键领域是教育公众从这些基因组信息中可以得出什么结论,并将基因组教育与已经在学术环境中教授的基础遗传原则相结合。个人基因组学提供疾病治疗的前景令人兴奋,但仍有许多挑战需要验证基因组预测和诊断相关性。关于如何使用个人基因组信息,还必须解决伦理和社会问题。这场基因组学革命为以个人的方式向学生、临床医生和公众传授科学和伦理问题提供了一个强大的机会,以增加学习效果。在这篇综述中,我们讨论了个人基因组学在社会中的影响,并重点介绍了基因组学教育在课堂、诊所和公众中的重要性和益处,并探讨了个人基因组教育的潜在后果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4ec5/7037382/f94bcf429119/ijms-21-00768-g001.jpg

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