早产儿贫血与肠道菌群失调的发生发展。
The development of intestinal dysbiosis in anemic preterm infants.
机构信息
College of Medicine, University of South Florida, Tampa, FL, 33606, USA.
College of Nursing, University of South Florida, Tampa, FL, USA.
出版信息
J Perinatol. 2020 Jul;40(7):1066-1074. doi: 10.1038/s41372-020-0599-z. Epub 2020 Jan 28.
OBJECTIVE
Anemia and Proteobacteria-dominant intestinal dysbiosis in very low birth weight (VLBW) infants have been linked to necrotizing enterocolitis, a severe gut inflammatory disease. We hypothesize that anemia of prematurity is related to the development of intestinal dysbiosis.
STUDY DESIGN
Three hundred and forty-two weekly stool samples collected prospectively from 80 VLBW infants were analyzed for bacterial microbiomes (with 16S rRNA). Linear mixed-effects model was used to determine the relationships between the onsets of anemia and intestinal dysbiosis.
RESULTS
Hematocrit was associated with intestinal microbiomes, with lower Hct occurring with increased Proteobacteria and decreased Firmicutes. Infants with a hematocrit <30% had intestinal microbiomes that diverged toward Proteobacteria dominance and low diversity after the first postnatal month. The microbiome changes were also related to the severity of anemia.
CONCLUSIONS
This finding supports a potential microbiological explanation for anemia as a risk factor for intestinal dysbiosis in preterm infants.
目的
极低出生体重（VLBW）婴儿的贫血和以变形菌门为主的肠道菌群失调与坏死性小肠结肠炎有关，这是一种严重的肠道炎症性疾病。我们假设早产儿贫血与肠道菌群失调的发展有关。
研究设计
前瞻性分析了 80 名极低出生体重儿每周采集的 342 份粪便样本，进行细菌微生物组（16S rRNA）分析。采用线性混合效应模型确定贫血和肠道菌群失调的发生之间的关系。
结果
血细胞比容与肠道微生物组有关，较低的 Hct 与变形菌门增加和Firmicutes减少有关。血细胞比容<30%的婴儿在出生后第一个月后，其肠道微生物组向变形菌门优势和低多样性转变。微生物组的变化也与贫血的严重程度有关。
结论
这一发现为早产儿贫血作为肠道菌群失调的危险因素提供了潜在的微生物学解释。
Zotero 插件