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一项关于老年孤立性髋部骨折手术时间和死亡率的为期三年的回顾性多中心研究。

A three-year retrospective multi-center study on time to surgery and mortality for isolated geriatric hip fractures.

作者信息

Tanner Ii Allen, Jarvis Stephanie, Orlando Alessandro, Nwafo Nnamdi, Madayag Robert, Roberts Zachary, Corrigan Chad, Carrick Matthew, Bourg Pamela, Smith Wade, Bar-Or David

机构信息

Penrose Hospital, 2222 North Nevada Ave, Colorado Springs, CO, 80907, USA.

ION Research, 383 Corona St. #319, Denver, CO, 80218, USA.

出版信息

J Clin Orthop Trauma. 2020 Feb;11(Suppl 1):S56-S61. doi: 10.1016/j.jcot.2019.12.001. Epub 2019 Dec 6.

Abstract

BACKGROUND

There are multiple reports on the effect of time to surgery for geriatric hip fractures; it remains unclear if earlier intervention is associated with improved mortality, hospital length of stay (HLOS), or cost.

METHODS

This was a multi-center retrospective cohort study. Patients (≥65y.) admitted (1/14-1/16) to six level 1 trauma centers for isolated hip fractures were included. Patients were dichotomized into early (≤24 h of admission) or delayed surgery (>24 h). The primary outcome was mortality using the CDC National Death Index. Secondary outcomes included HLOS, complications, and hospital cost.

RESULTS

There were 1346 patients, 467 (35%) delayed and 879 (65%) early. The early group had more females (70% vs. 61%, p < 0.001) than the delayed group. The delayed group had a median of 2 comorbidities, whereas the early group had 1, p < 0.001. Mortality and complications were not significantly different between groups. After adjustment, the delayed group had no statistically significant increased risk of dying within one year, OR: 1.1 (95% CI:0.8, 1.5), compared to the early group. The average difference in HLOS was 1.1 days longer for the delayed group, when compared to the early group, p-diff<0.001, after adjustment. The average difference in cost for the delayed group was $2450 ($1550, $3400) more expensive per patient, than the early group, p < 0.001.

CONCLUSIONS

The results of this study provide further evidence that surgery within 24 h of admission is not associated with lower odds of death when compared to surgery after 24 h of admission, even after adjustment. However, a significant decrease in cost and HLOS was observed for early surgery. If causally linked, our data are 95% confident that earlier treatment could have saved a maximum of $1,587,800. Early surgery should not be pursued purely for the motivation of reducing hospital costs.

LEVEL OF EVIDENCE

Level III.

摘要

背景

关于老年髋部骨折手术时机的影响已有多篇报道;早期干预是否与死亡率降低、住院时间(HLOS)缩短或成本降低相关仍不清楚。

方法

这是一项多中心回顾性队列研究。纳入了(1/14 - 1/16)因单纯髋部骨折入住六个一级创伤中心的患者(≥65岁)。患者被分为早期手术组(入院后≤24小时)或延迟手术组(>24小时)。主要结局是使用疾病预防控制中心国家死亡指数的死亡率。次要结局包括住院时间、并发症和住院费用。

结果

共有1346例患者,467例(35%)延迟手术,879例(65%)早期手术。早期手术组女性比例高于延迟手术组(70%对61%,p < 0.001)。延迟手术组的合并症中位数为2种,而早期手术组为1种,p < 0.001。两组之间的死亡率和并发症无显著差异。调整后,与早期手术组相比,延迟手术组在一年内死亡风险无统计学显著增加,OR:1.1(95%CI:0.8,1.5)。调整后,延迟手术组的平均住院时间比早期手术组长1.1天,p - diff < 0.001。延迟手术组的平均费用比早期手术组每位患者贵2450美元(1550美元,3400美元),p < 0.001。

结论

本研究结果进一步证明,即使在调整后,与入院24小时后手术相比,入院24小时内手术与较低的死亡几率无关。然而,早期手术可显著降低成本和缩短住院时间。如果存在因果关系,我们的数据有95%的把握认为早期治疗最多可节省1587800美元。不应仅仅为了降低医院成本而进行早期手术。

证据级别

三级。

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