Haleem Abid, Javaid Mohd, Khan Rizwan Hasan, Suman Rajiv
Department of Mechanical Engineering, Jamia Millia Islamia, New Delhi, India.
Interdisciplinary Biotechnology Unit, Aligarh Muslim University, Aligarh, India.
J Clin Orthop Trauma. 2020 Feb;11(Suppl 1):S118-S124. doi: 10.1016/j.jcot.2019.12.002. Epub 2019 Dec 14.
3D printing technology provides an excellent capability to manufacture customised implants for patients. Now, its applications are also successful in bone tissue engineering. This paper tries to provide a review of the applications of 3D printing in bone tissue engineering.
Searching by keywords, from the Scopus database, to identify relevant latest research articles on 3D printing in bone tissue engineering, through "3D printing" "bone tissue engineering". This study makes a bibliometric analysis of the identified research articles and identified major applications and steps.
3D printing technology creates innovative development in bone tissue engineering. It involves the manufacturing of a scaffold with the combination of cells and materials. We identified a total number of 257 research articles through bibliometric analysis by searching through keywords "3D printing" "bone tissue engineering". This paper studies 3D printing technology and its significant contributions, benefits and steps used for bone tissue engineering. Result discusses the essential elements of bone tissue engineering and identifies its five significant advancements when 3D printing is used. Finally, ten useful applications of 3D printing in bone tissue engineering are identified and studied with a brief description.
In orthopaedics, bone defects create a high impact on the quality of life of the patient. It leads to a higher demand for bone substitutes for replacement of bone defect. Bone tissue engineering can help to replace a critical defect bone. 3D printing is a useful technology for the fabrication of scaffolds critical in bone tissue engineering. There are different binders which can create bone scaffolds with requisite mechanical strength. These binders are used to create excellent osteoconductive, bioactive scaffolds. Computed tomography (CT) and Magnetic resonance imaging (MRI) help to provide images of specific defects of an individual patient, and these images can further be used for 3D printing the detective object. A bone defect caused by specific disease is sorted out by transplantation in clinical practice. Now a day bone tissue engineering opens a new option for this treatment of bone defects with the manufacturing of porous bone scaffold using 3D printing technology.
3D打印技术为制造适合患者的定制植入物提供了卓越的能力。目前，其在骨组织工程中的应用也取得了成功。本文旨在对3D打印在骨组织工程中的应用进行综述。
通过关键词搜索，从Scopus数据库中识别关于骨组织工程中3D打印的相关最新研究文章，搜索词为“3D打印”“骨组织工程”。本研究对识别出的研究文章进行文献计量分析，确定主要应用和步骤。
3D打印技术在骨组织工程中实现了创新发展。它涉及将细胞与材料结合制造支架。通过搜索关键词“3D打印”“骨组织工程”进行文献计量分析，我们共识别出257篇研究文章。本文研究了3D打印技术及其对骨组织工程的重大贡献、益处和使用步骤。结果讨论了骨组织工程的基本要素，并确定了使用3D打印时的五项重大进展。最后，确定并研究了3D打印在骨组织工程中的十种有用应用，并进行了简要描述。
在骨科领域，骨缺损对患者的生活质量有很大影响。这导致对用于替代骨缺损的骨替代物的需求增加。骨组织工程有助于替代严重缺损的骨头。3D打印是制造骨组织工程中关键支架的有用技术。有不同的粘合剂可用于制造具有所需机械强度 的骨支架。这些粘合剂用于制造具有优异骨传导性、生物活性的支架。计算机断层扫描（CT）和磁共振成像（MRI）有助于提供个体患者特定缺损的图像，这些图像可进一步用于3D打印检测对象。在临床实践中，通过移植来解决由特定疾病引起的骨缺损。如今，骨组织工程通过使用3D打印技术制造多孔骨支架，为骨缺损的治疗开辟了新的选择。
