Nguyen Luan Minh, Wang Yufeng, Quynh Vu Giao Thuy, Hoai Ta Qui Thanh, Tran Dieu Linh, Nguyen Ngoc Hoi, Van Tran Thuan, Zhang Chao, Nguyen Dai Hai
Institute of Advanced Technology, Vietnam Academy of Science and Technology 1B TL29 Street, An Phu Dong Ward Ho Chi Minh City 700000 Vietnam
Graduate University of Science and Technology, Vietnam Academy of Science and Technology 18 Hoang Quoc Viet Street, Nghia Do Ward Hanoi 100000 Vietnam.
Nanoscale Adv. 2025 Jul 28. doi: 10.1039/d5na00279f.
There has recently been a noticeable increase in the prevalence of bone-related conditions, including osteoarthritis, arthritis, fractures, bone cancer, and infections, thereby creating an urgent demand for advanced biomaterials in regenerative medicine. Among emerging candidates, metal-organic frameworks (MOFs), with their large surface area, tunable porosity, and inherent bioactivity, have demonstrated considerable potential in bone tissue engineering. Initially, research focused on pristine MOFs as bioactive scaffolds or drug delivery vehicles due to their capacity for controlled encapsulation and release of therapeutic agents. However, issues such as poor stability, potential toxicity, and limited mechanical strength have driven the development of MOF-based composites. By incorporating MOFs into hydrogels, electrospun fibers, biocements, and three-dimensional scaffolds, researchers have improved biocompatibility, enhanced structural integrity, and achieved synergistic effects on bone regeneration. Consequently, these composites offer multifunctional platforms that simultaneously provide mechanical support, local drug delivery, and osteoinductive cues. This review highlights recent advances in the field, analyzes key limitations, and emphasizes the need for systematic strategies in design, synthesis, and evaluation. Furthermore, the integration of computational modeling and machine learning is proposed as a promising direction for optimizing material performance and accelerating clinical translation. Ultimately, interdisciplinary collaboration will be essential to realize the full potential of next-generation MOF-based composites in bone repair and regenerative therapies.
最近，包括骨关节炎、关节炎、骨折、骨癌和感染在内的与骨骼相关疾病的患病率显著上升，从而催生了再生医学对先进生物材料的迫切需求。在新兴的候选材料中，金属有机框架（MOF）凭借其大表面积、可调孔隙率和固有的生物活性，在骨组织工程中展现出了巨大潜力。最初，由于其能够控制治疗剂的包封和释放，研究集中在原始MOF作为生物活性支架或药物递送载体上。然而，稳定性差、潜在毒性和机械强度有限等问题推动了基于MOF的复合材料的发展。通过将MOF纳入水凝胶、电纺纤维、生物水泥和三维支架中，研究人员提高了生物相容性，增强了结构完整性，并在骨再生方面实现了协同效应。因此，这些复合材料提供了多功能平台，可同时提供机械支撑、局部药物递送和骨诱导信号。本综述突出了该领域的最新进展，分析了关键局限性，并强调了在设计、合成和评估中采用系统策略的必要性。此外，提出将计算建模和机器学习相结合，作为优化材料性能和加速临床转化的一个有前景的方向。最终，跨学科合作对于充分发挥下一代基于MOF的复合材料在骨修复和再生治疗中的潜力至关重要。
