ElKhouly Aisha M, Youness R A, Gad M Z
Biochemistry Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Pharmaceutical Biology Department, Faculty of Pharmacy and Biotechnology, German University in Cairo, Cairo, Egypt.
Noncoding RNA Res. 2020 Jan 9;5(1):11-21. doi: 10.1016/j.ncrna.2020.01.001. eCollection 2020 Mar.
Despite historically known as "junk" DNA, nowadays non-coding RNA transcripts (ncRNAs) are considered as fundamental players in various physiological and pathological conditions. Nonetheless, any alteration in their expression level has been reported to be directly associated with the incidence and aggressiveness of several diseases. MicroRNAs (miRNAs) are the well-studied members of the ncRNAs family. Several reports have highlighted their crucial roles in the post-transcriptional manipulation of several signaling pathways in different pathological conditions. In this review, our main focus is the multifaceted microRNA-486 (miR-486). miR-486-5p and miR-486-3p have been reported to have central roles in several types oncological and non-oncological conditions such as lung, liver, breast cancers and autism, intervertebral disc degeneration and metabolic syndrome, respectively. Moreover, we spotted the light onto the pleiotropic role of miR-486-5p in acting as competing endogenous RNA with other members of ncRNAs family such as long non-coding RNAs.
尽管非编码RNA转录本（ncRNAs）在历史上被称为“垃圾”DNA，但如今它们被认为是各种生理和病理状况中的重要参与者。尽管如此，据报道它们表达水平的任何改变都与几种疾病的发病率和侵袭性直接相关。微小RNA（miRNAs）是ncRNAs家族中经过充分研究的成员。几份报告强调了它们在不同病理状况下对几种信号通路的转录后调控中的关键作用。在本综述中，我们主要关注的是多面性的微小RNA-486（miR-486）。据报道，miR-486-5p和miR-486-3p分别在几种类型的肿瘤和非肿瘤状况中发挥核心作用，如肺癌、肝癌、乳腺癌以及自闭症、椎间盘退变和代谢综合征。此外，我们还揭示了miR-486-5p作为竞争性内源RNA与ncRNAs家族其他成员（如长链非编码RNA）相互作用的多效性作用。
