Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Hussen Bashdar Mahmud, Taheri Mohammad, Samsami Majid
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Cancer Cell Int. 2022 Sep 13;22(1):282. doi: 10.1186/s12935-022-02702-y.
Sonic Hedgehog (Shh) signaling cascade is one of the complex signaling pathways that control the accurately organized developmental processes in multicellular organisms. This pathway has fundamental roles in the tumor formation and induction of resistance to conventional therapies. Numerous non-coding RNAs (ncRNAs) have been found to interact with Shh pathway to induce several pathogenic processes, including malignant and non-malignant disorders. Many of the Shh-interacting ncRNAs are oncogenes whose expressions have been increased in diverse malignancies. A number of Shh-targeting miRNAs such as miR-26a, miR-1471, miR-129-5p, miR-361-3p, miR-26b-5p and miR-361-3p have been found to be down-regulated in tumor tissues. In addition to malignant conditions, Shh-interacting ncRNAs can affect tissue regeneration and development of neurodegenerative disorders. XIST, LOC101930370, lncRNA-Hh, circBCBM1, SNHG6, LINC-PINT, TUG1 and LINC01426 are among long non-coding RNAs/circular RNAs that interact with Shh pathway. Moreover, miR-424, miR-26a, miR-1471, miR-125a, miR-210, miR-130a-5p, miR-199b, miR-155, let-7, miR-30c, miR-326, miR-26b-5p, miR-9, miR-132, miR-146a and miR-425-5p are among Shh-interacting miRNAs. The current review summarizes the interactions between ncRNAs and Shh in these contexts.
音猬因子（Shh）信号级联是控制多细胞生物中精确组织发育过程的复杂信号通路之一。该通路在肿瘤形成和对传统疗法的耐药性诱导中具有重要作用。已发现许多非编码RNA（ncRNA）与Shh通路相互作用，以诱导多种致病过程，包括恶性和非恶性疾病。许多与Shh相互作用的ncRNA是癌基因，其表达在多种恶性肿瘤中增加。已发现一些靶向Shh的微小RNA，如miR-26a、miR-1471、miR-129-5p、miR-361-3p、miR-26b-5p和miR-361-3p在肿瘤组织中表达下调。除了恶性疾病外，与Shh相互作用的ncRNA还可影响组织再生和神经退行性疾病的发展。XIST、LOC101930370、lncRNA-Hh、circBCBM1、SNHG6、LINC-PINT、TUG1和LINC01426是与Shh通路相互作用的长链非编码RNA/环状RNA。此外，miR-424、miR-26a、miR-1471、miR-125a、miR-210、miR-130a-5p、miR-199b、miR-155、let-7、miR-30c、miR-326、miR-26b-5p、miR-9、miR-132、miR-146a和miR-425-5p是与Shh相互作用的微小RNA。本综述总结了在这些情况下ncRNA与Shh之间的相互作用。
