College of Pharmacy, Yeungnam University, 280 Deahak-ro, Gyeongsan, 38541, Republic of Korea.
Department for Management of Science and Technology Development, Ton Duc Thang University, Ho Chi Minh City, Viet Nam.
Arch Pharm Res. 2020 Jan;43(1):32-45. doi: 10.1007/s12272-020-01218-1. Epub 2020 Jan 28.
Natural killer (NK) cells have emerged as a potent alternative immunotherapeutic approach to T cell therapy for cancer. Despite promising results from preclinical and clinical studies, numerous challenges have limited the application of NK cell-based therapy, including poor expansion of NK cells in vitro, their short in vivo life span, time-intensiveness, treatment complexities, and the cost burden of the treatment. Recent advancements in the development of immune cell-delivering nanosystems have led to promising strategies to overcome these limitations and enhance NK cell toxicity towards cancer cells. This review first summarizes the biological roles of NK cells and their tumoricidal mechanisms. NK cells, in the context of the immune system and the tumor microenvironment, have reportedly provided novel insights into specific therapeutic targets. Eventually, various strategies targeting NK cells using nanoplatforms to modulate the NK cell responses for effective cancer immunotherapy are described herein. Altogether, this review discusses the potential of nanotechnology in advancements in NK cell-based onco-immunotherapy.
自然杀伤 (NK) 细胞已成为癌症的 T 细胞治疗的一种有前途的免疫治疗替代方法。尽管临床前和临床研究取得了有希望的结果，但许多挑战限制了基于 NK 细胞的治疗的应用，包括 NK 细胞在体外的扩增不良、体内寿命短、时间密集、治疗复杂性以及治疗的成本负担。免疫细胞递送至纳米系统的最新进展带来了有希望的策略，可以克服这些限制并增强 NK 细胞对癌细胞的毒性。本综述首先总结了 NK 细胞的生物学作用及其溶瘤机制。NK 细胞在免疫系统和肿瘤微环境中，据报道为特定治疗靶点提供了新的见解。最终，本文描述了使用纳米平台针对 NK 细胞的各种策略，以调节 NK 细胞反应，从而实现有效的癌症免疫治疗。总之，本文讨论了纳米技术在 NK 细胞基于癌症免疫治疗进展方面的潜力。
