[自闭症谱系障碍儿童血液中的S100B蛋白]
[S100B protein in the blood of children with autism spectrum disorders].
作者信息
Golubova T F, Tsukurova La, Korsunskaya L L, Osipyan R R, Vlasenko S V, Savchuk E A
机构信息
Research Institute of Children's Balneology, Physiotherapy and Medical Rehabilitation, Yevpatoria, Russia.
Vernadsky Crimean Federal University, Georgievsky Medical Academy , Simferopol, Russia.
出版信息
Zh Nevrol Psikhiatr Im S S Korsakova. 2019;119(12):76-83. doi: 10.17116/jnevro201911912176.
AIM
To evaluate the plasma content of S100B protein in children with autism spectrum disorders (ASD).
MATERIAL AND METHODS
Forty-five children with autism (item F84 of ICD-10), aged from 6 to 15 years, were examined. The control group (KG) consisted of 25 healthy children. The study included examination by specialists, an assessment of the severity of the disease using the Children's Rating Scale of Autism scale (CARS), evaluation of S100B in blood serum.
RESULTS
The content of S100B in children with autism was significantly higher in comparison with KG. The level of S100B in children with ASD with abnormal development of brain structures (MRI) was significantly higher compared with KG and a group of children without signs of disturbance of brain structures. S100B levels were higher in children with severe ASD, and differed from controls in children with moderate ASD.
CONCLUSION
The majority of children with ASD show signs of stress of neuroprotective mechanisms, and children with anomalies of brain structures have signs of hypoxia of the brain and damage of the blood-brain barrier.
目的
评估自闭症谱系障碍（ASD）患儿血浆中S100B蛋白的含量。
材料与方法
对45名年龄在6至15岁的自闭症患儿（ICD - 10中的F84项）进行检查。对照组（KG）由25名健康儿童组成。该研究包括专家检查、使用儿童自闭症评定量表（CARS）评估疾病严重程度以及评估血清中的S100B。
结果
自闭症患儿的S100B含量与KG组相比显著更高。脑结构发育异常（MRI）的ASD患儿的S100B水平与KG组以及无脑结构紊乱迹象的儿童组相比显著更高。重度ASD患儿的S100B水平更高，且与中度ASD患儿的对照组存在差异。
结论
大多数ASD患儿表现出神经保护机制应激的迹象，而脑结构异常的患儿存在脑缺氧和血脑屏障受损的迹象。
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