Department of Pediatrics, The Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510630, Guangdong, China.
College of Horticulture, South China Agricultural University, Guangzhou, 510642, Guangdong, China.
J Autism Dev Disord. 2021 Aug;51(8):2569-2577. doi: 10.1007/s10803-020-04710-1.
The S100 calcium-binding protein beta subunit (S100B) protein, which mostly exists in the central nervous system, is commonly noted as a marker of neuronal damage. We conducted the first systematic review with meta-analysis to compare peripheral blood S100B levels in individuals with ASD with those in healthy controls. A systematic search was carried out for studies published before May 5, 2020. In total, this meta-analysis involved ten studies with 822 participants and 451 cases. The meta-analysis revealed that individuals with ASD had higher peripheral blood S100B levels than healthy controls [standardized mean difference (SMD) = 0.97, 95% confidence interval (95% CI) = 0.41-1.53; p < 0.001]. Peripheral blood S100B levels may have potential as a useful biomarker for ASD.
S100 钙结合蛋白β亚基（S100B）蛋白主要存在于中枢神经系统，通常被认为是神经元损伤的标志物。我们进行了首次系统评价和荟萃分析，以比较 ASD 患者和健康对照组外周血 S100B 水平。系统检索了截至 2020 年 5 月 5 日发表的研究。这项荟萃分析共纳入了 10 项研究，涉及 822 名参与者和 451 例病例。荟萃分析显示，ASD 患者外周血 S100B 水平高于健康对照组[标准化均数差（SMD）=0.97，95%置信区间（95%CI）=0.41-1.53；p<0.001]。外周血 S100B 水平可能有作为 ASD 有用生物标志物的潜力。
