Singapore Centre for Environmental Life Sciences Engineering, 60 Nanyang Drive, Singapore, 637551, Singapore.
Interdisciplinary Graduate School, Nanyang Technological University, 50 Nanyang Avenue, South Spine, Level B3, Block S2-B3a, Singapore, 639798, Singapore.
Proteomics. 2020 Mar;20(5-6):e1800419. doi: 10.1002/pmic.201800419. Epub 2020 Feb 24.
Microorganisms that colonize the gastrointestinal tract, collectively known as the gut microbiota, are known to produce small molecules and metabolites that significantly contribute to host intestinal development, functions, and homeostasis. Emerging insights from microbiome research reveal that gut microbiota-derived signals and molecules influence another key player maintaining intestinal homeostasis-the intestinal stem cell niche, which regulates epithelial self-renewal. In this review, the literature on gut microbiota-host crosstalk is surveyed, highlighting the effects of gut microbial metabolites on intestinal stem cells. The production of various classes of metabolites, their actions on intestinal stem cells are discussed and, finally, how the production and function of metabolites are modulated by aging and dietary intake is commented upon.
定植于胃肠道的微生物，统称为肠道微生物群，已知其能够产生小分子和代谢物，这些物质对宿主肠道的发育、功能和稳态有重要贡献。微生物组研究的新发现表明，肠道微生物群衍生的信号和分子会影响另一个维持肠道稳态的关键角色——肠道干细胞龛，它调节上皮细胞的自我更新。在这篇综述中，调查了肠道微生物群-宿主串扰的文献，强调了肠道微生物代谢物对肠道干细胞的影响。讨论了各种代谢物的产生及其对肠道干细胞的作用，最后还评论了代谢物的产生和功能如何受到衰老和饮食摄入的调节。
