Tan Bihui, Xiao Dingfu, Wang Jing, Tan Bi'e
Key Laboratory for Quality Regulation of Livestock and Poultry Products of Hunan Province, College of Animal Science and Technology, Hunan Agricultural University, Changsha 410128, China.
Yuelushan Laboratory, Changsha 410128, China.
Animals (Basel). 2024 Apr 19;14(8):1228. doi: 10.3390/ani14081228.
The gastrointestinal tract plays crucial roles in the digestion and absorption of nutrients, as well as in maintenance of a functional barrier. The development and maturation of the intestine is important for piglets to maintain optimal growth and health. Polyamines are necessary for the proliferation and growth of enterocytes, which play a key role in differentiation, migration, remodeling and integrity of the intestinal mucosa after injury. This review elaborates the development of the structure and function of the intestine of piglets during embryonic, suckling and weaning periods, the utilization and metabolism of polyamines in the intestine, as well as the role of polyamines in intestinal development and mucosal repair. The nutritional intervention to improve intestinal development and functions by modulating polyamine metabolism in piglets is also put forward. These results may help to promote the adaption to weaning in pigs and provide useful information for the development and health of piglets.
胃肠道在营养物质的消化和吸收以及维持功能性屏障方面发挥着关键作用。肠道的发育和成熟对于仔猪维持最佳生长和健康至关重要。多胺是肠上皮细胞增殖和生长所必需的，肠上皮细胞在损伤后肠道黏膜的分化、迁移、重塑和完整性方面起着关键作用。本文综述了仔猪在胚胎期、哺乳期和断奶期肠道结构和功能的发育、肠道中多胺的利用和代谢，以及多胺在肠道发育和黏膜修复中的作用。还提出了通过调节仔猪多胺代谢来改善肠道发育和功能的营养干预措施。这些结果可能有助于促进猪对断奶的适应，并为仔猪的发育和健康提供有用信息。
