通过血红素辅因子的功能化修饰得到一种优越的 G-四链体 DNA 酶。
A superior G-quadruplex DNAzyme through functionalized modification of the hemin cofactor.
机构信息
MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, 510275, China.
出版信息
Chem Commun (Camb). 2020 Feb 25;56(16):2427-2430. doi: 10.1039/c9cc09729e.
PMID:31995044
Abstract
Unlike previous studies that are generally based on the native cofactor, chemical modifications of the hemin structure through introducing new functionalities are proposed to enhance the catalytic efficiency of the hemin/G-quadruplex (hG4) DNAzyme. Functionalized hemin cofactors will highly improve the performance of the hG4 DNAzyme in future applications.
摘要
与以往通常基于天然辅因子的研究不同，通过引入新的功能来修饰血红素结构，从而提高血红素/G-四链体（hG4）DNA 酶的催化效率。功能化的血红素辅因子将极大地提高 hG4 DNA 酶在未来应用中的性能。
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