Lee Dongyun, Kim Bong-Jo, Han Ji Won, Kim Tae Hui, Kwak Kyung Phil, Kim Kayoung, Kim Shin Gyeom, Kim Jeong Lan, Kim Tae Hyun, Moon Seok Woo, Park Jae Young, Park Joon Hyuk, Byun Seonjeong, Suh Seung Wan, Seo Ji Young, So Yoonseop, Ryu Seung-Ho, Youn Jong Chul, Lee Kyoung Hwan, Lee Dong Young, Lee Dong Woo, Lee Seok Bum, Lee Jung Jae, Lee Ju Ri, Jeong Hyeon, Jeong Hyun-Ghang, Jhoo Jin Hyeong, Han Kyuhee, Hong Jong Woo, Bae Jong Bin, Kim Ki Woong
Department of Psychiatry, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea.
Department of Psychiatry, Gyeongsang National University College of Medicine, Jinju, Republic of Korea.
Psychiatry Investig. 2020 Jan;17(1):21-28. doi: 10.30773/pi.2019.0105. Epub 2020 Jan 25.
Cardiovascular diseases are representative risk factors for the onset of cognitive decline. The purpose of this study was to confirm the relationship between diastolic blood pressure and cognitive function in elderly people in Korea.
Data from subjects who were enrolled in the prospective Korean Longitudinal Study on Cognitive Aging and Dementia were used in this study. Data from 701 subjects whose diastolic blood pressure range did not change (≤79 mm Hg or ≥80 mm Hg) over 2 years were analyzed. To analyze the differences in cognitive function between the groups at the 2-year follow-up, an analysis of covariance was performed with covariates, which were significantly different between the two groups, and the baseline cognitive function.
Significant differences were observed between the two groups, and the mean scores on the constructional praxis (η2=0.010) and word list recall tests (η2=0.018) in the diastolic blood pressure ≥80 mm Hg group were higher than those in the diastolic blood pressure ≤79 mm Hg group at the 2-year follow-up.
These results indicate that maintaining a DBP below 79 mm Hg presents a greater risk of cognitive decline in Korean elderly people.
心血管疾病是认知功能下降发病的典型风险因素。本研究的目的是证实韩国老年人舒张压与认知功能之间的关系。
本研究使用了参与韩国认知衰老与痴呆前瞻性纵向研究的受试者数据。分析了701名受试者的数据，这些受试者的舒张压范围在2年内未发生变化（≤79毫米汞柱或≥80毫米汞柱）。为了分析两组在2年随访时认知功能的差异，对两组之间有显著差异的协变量以及基线认知功能进行了协方差分析。
两组之间观察到显著差异，在2年随访时，舒张压≥80毫米汞柱组在构建实践（η2 = 0.010）和单词列表回忆测试（η2 = 0.018）中的平均得分高于舒张压≤79毫米汞柱组。
这些结果表明，韩国老年人将舒张压维持在79毫米汞柱以下会出现更大的认知功能下降风险。
