Alterio Daniela, Tagliabue Marta, Muto Matteo, Zorzi Stefano, Volpe Stefania, Gandini Sara, Sibio Daniela, Bayır Ömer, Marvaso Giulia, Ferrari Annamaria, Bruschini Roberto, Cossu Rocca Maria, Preda Lorenzo, Marangoni Roberta, Starzynska Anna, Vigorito Sabrina, Ansarin Mohssen, Jereczek-Fossa Barbara Alicja
Department of Radiotherapy, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Division of Otolaryngology and Head and Neck Surgery, IEO, European Institute of Oncology, IRCCS, Milan, Italy.
Tumori. 2020 Dec;106(6):471-479. doi: 10.1177/0300891619900920. Epub 2020 Jan 30.
Postoperative radiotherapy (PORT) is indicated in almost two-thirds of patients treated with transoral robotic surgery (TORS) for head and neck tumors. The aim of this study was to quantify the toxicity profile of patients treated with PORT after TORS in oropharyngeal and supraglottic laryngeal cancer focusing on soft tissue necrosis (STN).
We retrospectively reviewed 28 patients. Acute and late toxicity were examined. Incidence and severity of STN were recorded.
No patient experienced acute grade 3 skin or mucosal toxicity; 1 patient had grade 3 dysphagia. At 12 months, no evaluated patient required enteral nutrition and 2 patients had tracheostomy. STN occurred in 4 (14%) patients: 3 out of 4 (75%) patients with STN had diabetes, whereas 6 out of 13 (25%) patients without STN had diabetes ( = 0.05).
We found an acceptable toxicity profile of PORT performed after a TORS procedure. Diabetes mellitus might be a risk factor for STN.
对于接受经口机器人手术（TORS）治疗的头颈部肿瘤患者，近三分之二的患者需要术后放疗（PORT）。本研究旨在量化接受PORT治疗的口咽癌和声门上喉癌患者在TORS术后的毒性特征，重点关注软组织坏死（STN）。
我们回顾性分析了28例患者。检查急性和晚期毒性。记录STN的发生率和严重程度。
无患者出现急性3级皮肤或黏膜毒性；1例患者出现3级吞咽困难。在12个月时，无评估患者需要肠内营养，2例患者行气管切开术。4例（14%）患者发生STN：4例STN患者中有3例（75%）患有糖尿病，而13例无STN患者中有6例（25%）患有糖尿病（P = 0.05）。
我们发现TORS术后进行PORT的毒性特征是可以接受的。糖尿病可能是STN的一个危险因素。
