用头孢他啶-阿维巴坦检测一组分离菌时肉汤微量稀释法与纸片扩散法结果的相关性：一项多实验室研究的结果
Correlation between Broth Microdilution and Disk Diffusion Results when Testing Ceftazidime-Avibactam against a Challenge Collection of Isolates: Results from a Multilaboratory Study.
作者信息
Sader Helio S, Rhomberg Paul R, Chandrasekaran Sukantha, Trejo Marisol, Fedler Kelley A, Boyken Linda D, Diekema Daniel J
机构信息
JMI Laboratories, North Liberty, Iowa, USA
JMI Laboratories, North Liberty, Iowa, USA.
出版信息
J Clin Microbiol. 2020 Mar 25;58(4). doi: 10.1128/JCM.01757-19.
Abstract
We assessed the ceftazidime-avibactam disk diffusion breakpoints that provide the lowest discrepancy error rates by testing an isolate collection with ceftazidime-avibactam MIC values near the breakpoints. Isolates ( = 112) were susceptibility tested by broth microdilution and disk diffusion methods in 3 laboratories. Current disk diffusion breakpoints (≥21/≤20 mm for susceptible/resistant) provided the lowest error rates, but confirmatory MIC testing is indicated for isolates with inhibition zones of 20 to 22 mm.
摘要
我们通过测试一组最低抑菌浓度（MIC）值接近断点的头孢他啶-阿维巴坦分离株，评估了能提供最低差异错误率的头孢他啶-阿维巴坦纸片扩散法断点。在3个实验室中，采用肉汤微量稀释法和纸片扩散法对112株分离株进行了药敏试验。当前的纸片扩散法断点（敏感/耐药分别为≥21/≤20 mm）提供了最低的错误率，但对于抑菌圈直径为20至22 mm的分离株，仍需进行确证性MIC检测。
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