Xu Zhenglei, Shi Ruiyue, Zhang Ru, Zhang Dingguo, Wang Lisheng
Department of Gastroenterology, Shenzhen People's Hospital, Second Clinical Medical College, Jinan University, Shenzhen, 518000, Guangdong Province, China.
Tumour Biol. 2013 Dec;34(6):4001-5. doi: 10.1007/s13277-013-0989-3. Epub 2013 Aug 1.
Tumor necrosis factor β (TNF-β) 252 A/G polymorphism has been implicated to be associated with risk of gastric cancer, but previous studies showed inconsistent and inconclusive results. Therefore, we performed a meta-analysis to assess the association between TNF-β 252 A/G polymorphism and gastric cancer risk. Relevant studies were searched from PubMed database. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of the associations between TNF-β 252 A/G polymorphism and gastric cancer risk. Overall, 11 individual case-control studies with 2,270 cases and 4,404 controls were included in the final meta-analysis. Meta-analysis of total 11 studies showed that TNF-β 252 A/G polymorphism was associated with the risk of gastric cancer (G vs. A: OR = 1.10, 95% CI 1.02-1.19, P = 0.015; GG/AG vs. AA: OR = 1.21, 95% CI 1.00-1.47, P = 0.049). Subgroup analysis by ethnicity showed that TNF-β 252 A/G polymorphism was only associated with the risk of gastric cancer in Asians, but not Caucasians. The findings from the current meta-analysis suggest that TNF-β 252 A/G polymorphism is associated with the risk of gastric cancer, especially in Asians.
肿瘤坏死因子β（TNF-β）252 A/G多态性被认为与胃癌风险相关，但先前的研究结果并不一致且尚无定论。因此，我们进行了一项荟萃分析，以评估TNF-β 252 A/G多态性与胃癌风险之间的关联。从PubMed数据库中检索相关研究。计算比值比（OR）和95%置信区间（95%CI），以评估TNF-β 252 A/G多态性与胃癌风险之间关联的强度。总体而言，最终的荟萃分析纳入了11项个体病例对照研究，共2270例病例和4404例对照。对这11项研究的荟萃分析表明，TNF-β 252 A/G多态性与胃癌风险相关（G vs. A：OR = 1.10，95%CI 1.02 - 1.19，P = 0.015；GG/AG vs. AA：OR = 1.21，95%CI 1.00 - 1.47，P = 0.049）。按种族进行的亚组分析表明，TNF-β 252 A/G多态性仅与亚洲人的胃癌风险相关，与高加索人无关。当前荟萃分析的结果表明，TNF-β 252 A/G多态性与胃癌风险相关，尤其是在亚洲人中。
