School of Public Health, University College Cork, Cork, Ireland.
School of Medicine, University College Cork, Cork, Ireland.
Int J Obes (Lond). 2020 Oct;44(10):2035-2043. doi: 10.1038/s41366-020-0538-2. Epub 2020 Jan 29.
Standardisation of outcomes measured and reported in trials of infant-feeding interventions to prevent childhood obesity is essential to evaluate and synthesise intervention effects. The aim of this study is to develop an infant-feeding core outcome set for use in randomised trials of infant-feeding interventions, with children ≤1 year old, to prevent childhood obesity.
Core outcome set development followed four stages: (1) systematic review of outcomes reported in the extant literature; (2) meeting with national and international stakeholders to discuss and clarify identified outcomes; (3) e-Delphi study with national and international stakeholders to prioritise outcomes; (4) meeting with national and international stakeholders to reach consensus on outcomes. Stakeholders in stages 2-4 were paediatricians, general practitioners, nurses, midwives, non-clinician researchers, parents, dieticians, nutritionists, and childcare providers.
Twenty-six outcomes were identified for inclusion in the core outcome set. These were grouped in nine outcome domains: 'breastfeeding and formula feeding', 'introduction of solids', 'parent feeding practices and styles', 'parent knowledge and beliefs', 'practical feeding', 'food environment', 'dietary intake', 'perceptions of infant behaviour and preferences', and 'child weight'.
The core outcome set identified in this study is the minimum that should be measured and reported in trials of infant-feeding interventions to prevent childhood obesity. This standardisation of outcomes will enable more comprehensive examination and synthesis of the effects of infant-feeding interventions to prevent childhood obesity.
为了评估和综合干预效果，对预防儿童肥胖的婴儿喂养干预措施进行的临床试验中，测量和报告的结果必须标准化。本研究旨在为预防儿童肥胖的婴儿喂养干预措施的随机试验制定婴儿喂养核心结局集。
核心结局集的开发遵循四个阶段：（1）对现有文献中报告的结果进行系统回顾；（2）与国家和国际利益相关者举行会议，讨论并澄清确定的结果；（3）对国家和国际利益相关者进行电子德尔菲研究，以确定优先结果；（4）与国家和国际利益相关者举行会议，就结果达成共识。第 2-4 阶段的利益相关者包括儿科医生、全科医生、护士、助产士、非临床研究人员、父母、营养师、营养学家和儿童保育提供者。
确定了 26 个纳入核心结局集的结果。这些结果分为九个结果领域：“母乳喂养和配方奶喂养”、“固体食物的引入”、“父母喂养行为和风格”、“父母的知识和信念”、“实际喂养”、“食物环境”、“饮食摄入”、“对婴儿行为和偏好的看法”和“儿童体重”。
本研究确定的核心结局集是预防儿童肥胖的婴儿喂养干预措施试验中应测量和报告的最低要求。这些结果的标准化将能够更全面地检查和综合婴儿喂养干预措施预防儿童肥胖的效果。
