Rehabilitation Department, Great North Children's Hospital, Newcastle Upon Tyne, UK
Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne, UK.
BMJ Paediatr Open. 2022 Oct;6(1). doi: 10.1136/bmjpo-2022-001537.
Indicators of child health have the potential to inform societal conversations, decision-making and prioritisation. Paediatric core outcome sets are an increasingly common way of identifying a minimum set of outcomes for trials within clinical groups. Exploring commonality across existing sets may give insight into universally important and inclusive child health indicators.
A search of the Core Outcome Measures in Effectiveness Trial register from 2008 to 2022 was carried out. Eligible articles were those reporting on core outcome sets focused on children and young people aged 0-18 years old. The International Classification of Functioning, Disability and Health (ICF) was used as a framework to categorise extracted outcomes. Information about the involvement of children, young people and their families in the development of sets was also extracted.
206 articles were identified, of which 36 were included. 441 unique outcomes were extracted, mapping to 22 outcome clusters present across multiple sets. Medical diagnostic outcomes were the biggest cluster, followed by pain, communication and social interaction, mobility, self-care and school. Children and young people's views were under-represented across core outcome sets, with only 36% of reviewed studies including them at any stage of development.
Existing paediatric core outcome sets show overlap in key outcomes, suggesting the potential for generic child health measurement frameworks. It is unclear whether existing sets best reflect health dimensions important to children and young people, and there is a need for better child and young person involvement in health indicator development to address this.
儿童健康指标有可能为社会对话、决策和重点工作提供信息。儿科核心结局指标是在临床群组内确定试验最小结局集的一种越来越常见的方法。探索现有结局指标集的共同性可以深入了解普遍重要和包容的儿童健康指标。
对 2008 年至 2022 年期间核心结局测量在有效性试验登记处进行了检索。符合条件的文章是那些报告了针对 0-18 岁儿童和青少年的核心结局指标集的文章。国际功能、残疾和健康分类（ICF）被用作对提取结局进行分类的框架。还提取了关于儿童、青少年及其家庭参与结局指标集制定的信息。
共确定了 206 篇文章，其中 36 篇被纳入。共提取了 441 个独特的结局，映射到多个结局指标集中存在的 22 个结局集群。医疗诊断结局是最大的集群，其次是疼痛、沟通和社会互动、移动性、自我护理和学校。儿童和青少年的观点在核心结局指标集中代表性不足，只有 36%的综述研究在任何发展阶段都包括他们。
现有的儿科核心结局指标集在关键结局方面存在重叠，这表明存在通用的儿童健康测量框架的可能性。目前尚不清楚现有结局指标集是否最好地反映了儿童和青少年重要的健康维度，需要更好地让儿童和青少年参与健康指标的制定，以解决这一问题。
